Author

K. Gharzeddine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:biophysical modeling· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:metabolomics· 2 Assay:proteomics· 2

Frequent Co-Authors

A. MILLET· 3 shared F. Thomas· 2 shared G. Roth· 2 shared M. Malier· 2 shared A. Ortega· 1 shared C. Botte· 1 shared C. Gonzales Pietro· 1 shared C. Hennot· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersImmunology

A. MILLET

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Metabolic reprogramming of hypoxic tumour-associated macrophages through CSF-1R targeting favours treatment efficiency in colorectal cancers

K. Gharzeddine, C. Gonzales Pietro, M. Malier, C. Hennot, R. Grespan, Y. Yamaryo, C. Botte, F. Thomas, M. H. Laverriere, E. Girard, G. Roth, A. MILLET

This study shows that blocking CSF-1R in tumor-associated macrophages alters their metabolism, enhancing sensitivity to 5-fluorouracil in colorectal cancer.

bioRxiv · Feb 22, 2024 · PreprintImmunology

Coupled mechanical mapping and interference contrast microscopy reveal viscoelastic and adhesion hallmarks of monocytes differentiation into macrophages

M. Eroles, J. Lopez-Alonso, A. Ortega, T. Boudier, K. Gharzeddine, F. Lafont, A. Millet, C. Valotteau, F. Rico

This study uses mechanical and adhesion imaging to show that macrophages become stiffer and more adhesive than monocytes during differentiation.

bioRxiv · Nov 29, 2022Biophysics

Hypoxia Drives Dihydropyrimidine Dehydrogenase Expression in Macrophages and Confers Chemoresistance in Colorectal Cancer

M. MALIER, M. COURT, K. GHARZEDDINE, M. LAVERRIERE, S. MARSILI, F. THOMAS, T. DECAENS, G. ROTH, A. MILLET

This study identifies hypoxia-driven DPD expression in tumor-associated macrophages as a mechanism of 5-FU chemoresistance in colorectal cancer, with species-specific differences observed between human and mouse models.

bioRxiv · Oct 15, 2020Cell Biology