Hypoxia Drives Dihydropyrimidine Dehydrogenase Expression in Macrophages and Confers Chemoresistance in Colorectal Cancer
M. MALIER, M. COURT, K. GHARZEDDINE, M. LAVERRIERE, S. MARSILI, F. THOMAS, T. DECAENS, G. ROTH, A. MILLET
This study identifies hypoxia-driven DPD expression in tumor-associated macrophages as a mechanism of 5-FU chemoresistance in colorectal cancer, with species-specific differences observed between human and mouse models.
bioRxiv · Oct 15, 2020Cell Biology