G. Roth

Ecological diversification in sexual and asexual lineages

This study investigates how reproductive mode affects ecological diversification by comparing sexual and asexual lineages, finding that sexual reproduction promotes faster niche occupancy and higher diversity.

Metabolic reprogramming of hypoxic tumour-associated macrophages through CSF-1R targeting favours treatment efficiency in colorectal cancers

This study shows that blocking CSF-1R in tumor-associated macrophages alters their metabolism, enhancing sensitivity to 5-fluorouracil in colorectal cancer.

Targeting PPT1 with ezurpimtrostat sensitives liver tumor to immunotherapy by switching cold into hot microenvironments

This paper shows that inhibiting PPT1 with ezurpimtrostat enhances anti-PD-1 immunotherapy in liver cancer by converting cold to hot tumors.

Delivery of CAR-T Cells in a Transient Injectable Stimulatory Hydrogel Niche Improves Treatment of Solid Tumors

This paper develops an injectable hydrogel to co-deliver CAR-T cells and cytokines, enhancing solid tumor treatment in mice by creating a transient inflammatory niche.

A SARS-CoV-2 neutralizing antibody selected from COVID-19 patients by phage display is binding to the ACE2-RBD interface and is tolerant to most known recently emerging RBD mutations

The paper describes the selection of a SARS-CoV-2 neutralizing antibody from COVID-19 patients using phage display, showing it binds the ACE2-RBD interface and remains effective against emerging RBD mutations.

Hypoxia Drives Dihydropyrimidine Dehydrogenase Expression in Macrophages and Confers Chemoresistance in Colorectal Cancer

This study identifies hypoxia-driven DPD expression in tumor-associated macrophages as a mechanism of 5-FU chemoresistance in colorectal cancer, with species-specific differences observed between human and mouse models.

GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions

This paper evaluates GNS561, a PPT1 inhibitor, showing its efficacy against HCC by modulating lysosomal functions and inducing cell death in vitro and in vivo.

A modelling exercise to show why population models should incorporate distinct life histories of dispersers

The paper demonstrates that incorporating individual-level dispersal life history differences into population models affects population dynamics and growth rates.

SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface

The paper identifies potent SARS-CoV-2 neutralizing antibodies from pre-pandemic human donors that bind the RBD-ACE2 interface, showing high neutralization efficacy in vitro.

Single-molecule imaging reveals translation of mRNAs localized to stress granules

This study uses single-molecule imaging to show that mRNAs localized to stress granules are translated, challenging the assumption that SGs exclusively contain nontranslating mRNA.