K. Göpfrich

DNA microbeads for spatio-temporally controlled morphogen release within organoids

This paper introduces DNA microbeads to control morphogen release in organoids, enabling spatio-temporal regulation of development and improving tissue mimicry.

Self-assembly and contraction of micron-scale DNA rings

This paper describes the creation of DNA-based contractile rings that can contract through two mechanisms, expanding DNA nanotechnology applications.

A DNA segregation module for synthetic cells

This paper develops an entropy-driven DNA segregation module using DNA Y-motifs in synthetic cells, showing controlled segregation via cleavage and environmental factors.

Mechanochemical signal transduction in synthetic cells

This study designs DNA origami signaling units that mechanically couple to DNA cytoskeletons in synthetic cells, enabling both chemical and mechanical transmembrane signaling.

Choice of fluorophore affects dynamic DNA nanostructures

This study shows that fluorophore choice can alter DNA nanostructure dynamics without changing DNA sequences, using experiments, MD simulations, and reaction-diffusion modeling.

Protein-free division of giant unilamellar vesicles controlled by enzymatic activity

This study demonstrates protein-free division of giant unilamellar vesicles using phase separation and osmosis, showing that water evaporation and metabolic activity can regulate this process.

Outperforming nature: synthetic enzyme built from DNA flips lipids of biological membranes at record rates

This paper describes a synthetic DNA enzyme that rapidly transports lipids between membrane leaflets, outperforming natural enzymes by three orders of magnitude.