S. Diez

Tubulin tyrosination/detyrosination governs the spatial segregation of intraflagellar transport trains on axonemal microtubule doublets

This study shows that tubulin tyrosination/detyrosination governs the spatial segregation of IFT trains on ciliary microtubules, preventing traffic jams.

Twist - torsion coupling in beating axonemes

The paper measures torsion and twist in axonemes of Chlamydomonas reinhardtii, finding co-rotation between cross-section and bending plane, indicating twist-torsion coupling.

Gliding motility of the diatom Craspedostauros australis correlates with the intracellular movement of raphid-specific myosins

This study identifies and characterizes raphid diatom-specific myosins in Craspedostauros australis, showing that only CaMyoB-D moves during gliding, suggesting a role in force generation.

Human kinesin-5 KIF11 drives the helical motion of anti-parallel and parallel microtubules around each other

This study shows that human kinesin-5 KIF11 drives helical motion and orbiting of microtubules, enabling flexible filament organization and torque regulation during mitosis.

Self-assembly and contraction of micron-scale DNA rings

This paper describes the creation of DNA-based contractile rings that can contract through two mechanisms, expanding DNA nanotechnology applications.

Vesicles driven by dynein and kinesin exhibit directional reversals without external regulators

This study shows that directional reversals in intracellular transport can occur without external regulators, using a minimal in vitro system of vesicles propelled by dynein and kinesin.

Crosstalk between guanosine nucleotides regulates cellular heterogeneity in protein synthesis during nutrient limitation

The paper identifies how guanosine nucleotides regulate protein synthesis heterogeneity in Bacillus subtilis under nutrient limitation by showing the differential roles of SasA, SasB, and RelA.

Intraflagellar transport trains can turn around without the ciliary tip complex

This study shows that intraflagellar transport trains can turn around without a dedicated calcium-dependent tip complex in Chlamydomonas reinhardtii.

Highly-parallel microfluidics-based force spectroscopy on single cytoskeletal motors

This paper introduces a microfluidics-based method to rapidly measure force-dependent motility parameters of kinesin-1 motors with improved throughput.

Stable tug-of-war between kinesin-1 and cytoplasmic dynein upon different ATP and roadblock concentrations

The paper investigates how ATP concentration and roadblock density affect bidirectional transport by kinesin-1 and dynein motors, finding that motor numbers determine transport direction and velocity, while ATP and roadblocks have minimal impact.

Intrinsically disordered domain of kinesin-3 Kif14 enables unique functional diversity

This study identifies the intrinsically disordered N-terminal domain of Kif14 as enabling its unique functional diversity through enhanced microtubule interactions and processivity.

Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments

This study shows TRAK1 enhances kinesin-1 transport efficiency in crowded environments by enabling obstacle navigation and increased run length.

Anillin propels myosin-independent constriction of actin rings

This study shows anillin drives myosin-independent actin ring constriction by generating forces that maximize filament overlap.

(p)ppGpp directly regulates translation initiation during entry into quiescence

This study shows that (p)ppGpp inhibits protein synthesis in Bacillus subtilis during quiescence by targeting the GTPase IF2, preventing its allosteric activation during translation initiation.

The kinesin-14, Ncd, drives a right-handed, helical motion of antiparallel microtubules around each other

This study investigates the motion of microtubules driven by the kinesin-14 Ncd, revealing right-handed helical motion in antiparallel configurations and static behavior in parallel ones.

A Brownian ratchet model explains the biased sidestepping movement of single-headed kinesin-3 KIF1A

The paper explains how single-headed KIF1A motors produce left-handed helical motion by sidestepping on microtubules, using experimental and simulation data.

Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymes

This study shows tau forms distinct kinetic phases on microtubules that regulate kinesin motors and severing enzymes like katanin.

Challenges in estimating the motility parameters of single processive motor proteins

This paper addresses challenges in estimating motility parameters of single processive motor proteins by proposing a unified algorithm to correct for finite filament length and photobleaching, with validation using simulated and experimental data.

Local Nucleation Of Microtubule Bundles Through Tubulin Concentration Into A Condensed Tau Phase

The paper shows that tau forms liquid droplets that concentrate tubulin, enabling local microtubule bundle nucleation without centrosomes.