J. Yoo

Comparison of the mechanism of antimicrobial action of the gold(I) compound auranofin in Gram-positive and Gram-negative bacteria

This paper investigates how auranofin affects Gram-positive and Gram-negative bacteria, finding that Gram-negative bacteria are more resistant due to efflux systems and glutathione levels.

The role of positively charged small biomolecules in the aggregation of hyperphosphorylated tau in Alzheimer's disease

This study identifies electrostatic interactions between hyperphosphorylated tau and polyamines as crucial for tau aggregation in Alzheimer's disease and observes the transition from aggregates to fibrils.

In vitro broad-spectrum antiviral activity of MIT-001, a mitochondria-targeted reactive oxygen species scavenger, against severe acute respiratory syndrome coronavirus 2 and multiple zoonotic viruses

This study evaluates MIT-001's antiviral activity against SARS-CoV-2 and zoonotic viruses in vitro, showing inhibition of viral replication and restoration of antioxidant gene expression.

Three-dimensional genomic mapping of human pancreatic tissue reveals striking multifocality and genetic heterogeneity in precancerous lesions

This study uses 3D imaging and genomic analysis to show that human pancreatic precancerous lesions (PanINs) are highly multifocal and genetically heterogeneous.

Sleeve gastrectomy promotes colitis-associated colorectal cancer in a murine model via a modified gut microbiome

This study shows that sleeve gastrectomy worsens colitis-associated colorectal cancer in mice by altering the gut microbiome, which can independently promote tumor growth.

A novel vascular endothelial growth factor-trap KP-VR2 with enhanced ligand blocking

This study develops KP-VR2, a novel VEGF-Trap that neutralizes VEGF-A, VEGF-B, and PlGF, showing improved antitumor efficacy compared to existing therapies.

Heterogeneous aggregation of amyloid-β 42 from single-molecule spectroscopy

This study uses single-molecule spectroscopy and deep learning to analyze the heterogeneous aggregation of Aβ42, revealing low oligomer concentrations and diverse conformations, and proposes a new aggregation model.

Generation of tonsil organoids as an ex vivo model for SARS-CoV-2 infection

This study established tonsil epithelial cell-derived organoids and demonstrated their feasibility as an ex vivo model for SARS-CoV-2 infection.

Improved Parameterization of Protein-DNA Interactions for Molecular Dynamics Simulations of PCNA Diffusion on DNA

The paper evaluates protein-DNA interaction parameters in AMBER and CHARMM force fields and proposes optimized Lennard-Jones parameters to better match experimental diffusion coefficients of PCNA on DNA.

Outperforming nature: synthetic enzyme built from DNA flips lipids of biological membranes at record rates

This paper describes a synthetic DNA enzyme that rapidly transports lipids between membrane leaflets, outperforming natural enzymes by three orders of magnitude.