Author

I. Rissanen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:structural biology· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Research Focus:protein structure prediction· 2 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

J. T. Huiskonen· 4 shared O. Vapalahti· 3 shared T. A. Bowden· 3 shared A. Kipar· 2 shared B. Lee· 2 shared J. Hepojoki· 2 shared K. Harlos· 2 shared L. Hannula· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersMicrobiology

J. T. Huiskonen

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Author profile →

6 papers

Recent·Most cited

Crystal structure and solution state of the C-terminal head region of the narmovirus receptor binding protein

A. J. Stelfox, K. Y. Oguntuyo, I. Rissanen, K. Harlos, R. Rambo, B. Lee, T. A. Bowden

This paper determines the crystal structure and solution state of the C-terminal head region of the receptor-binding proteins from Mossman and Nariva viruses, revealing structural differences from other paramyxoviruses.

mBio · Oct 31, 2023Peer-reviewedBiochemistry

Nanobody engineering for SARS-CoV-2 neutralization and detection

L. Hannula, S. Kuivanen, J. Lasham, R. Kant, L. Kareinen, M. Bogacheva, T. Strandin, T. Sironen, V. Sharma, P. Saviranta, A. Kipar, O. Vapalahti, J. T. Huiskonen, I. Rissanen

This study engineers nanobodies to neutralize SARS-CoV-2 variants and develop a detection assay, showing high potency against some variants but limitations against others.

bioRxiv · Sep 14, 2022Microbiology

New Vista into Origins of Viruses from a Prototypic ssDNA Phage

N. Kejzar, E. Laanto, I. Rissanen, V. Abrishami, M. Selvaraj, S. Moineau, J. Ravantti, L.-R. Sundberg, J. T. Huiskonen

The paper characterizes a lipid-containing ssDNA phage, {Phi}CjT23, and suggests it represents a model for the last common ancestor of ssDNA and dsDNA viruses in the Bamfordvirae.

bioRxiv · May 27, 2022 · PreprintMicrobiology

Intranasal inhibitor broadly blocks SARS-CoV-2 including recent highly immunoevasive Omicron subvariants

A. R. Mäkelä, H. Ugurlu, L. Hannula, P. Salminen, R. Kant, R. Fagerlund, S. Mäki, A. Haveri, T. Strandin, L. Kareinen, J. Hepojoki, L. Levanov, A. Pasternack, R. A. Naves, O. Ritvos, , K. Saksela

This paper describes a novel intranasal inhibitor, TriSb92, that effectively neutralizes SARS-CoV-2 and recent Omicron subvariants, offering protection against infection in mice.

bioRxiv · Dec 28, 2021 · PreprintMicrobiology

Molecular rationale for hantavirus neutralization by a reservoir host-derived monoclonal antibody

I. Rissanen, R. Stass, S. A. Krumm, J. Seow, R. J. G. Hulswit, G. C. Paesen, J. Hepojoki, O. Vapalahti, A. Lundkvist, O. Reynard, V. Volchkov, K. J. Doores, J. T. Huiskonen, T. A. Bowden

This study investigates how a monoclonal antibody neutralizes hantaviruses by targeting the glycoprotein lattice, revealing structural insights into antibody binding and its impact on viral entry.

bioRxiv · Apr 17, 2020Microbiology

A key region of molecular specificity orchestrates unique ephrin-B1 utilization by Cedar virus

R. Pryce, K. Azarm, I. Rissanen, K. Harlos, T. A. Bowden, B. Lee

This study identifies a key molecular region in Cedar virus glycoprotein that determines its unique utilization of ephrin-B1 as an entry receptor, distinct from other HNVs.

bioRxiv · Aug 5, 2019Microbiology