T. A. Bowden

Crystal structure and solution state of the C-terminal head region of the narmovirus receptor binding protein

This paper determines the crystal structure and solution state of the C-terminal head region of the receptor-binding proteins from Mossman and Nariva viruses, revealing structural differences from other paramyxoviruses.

VelcroVax: a bolt-on vaccine platform technology improves antibody titres against a viral glycoprotein in mice

VelcroVax is a vaccine platform that enhances antibody titres against a viral glycoprotein in mice by combining a modified VLP with a SUMO-tagged antigen.

Structure of trimeric pre-fusion rabies virus glycoprotein in complex with two protective antibodies

The paper reports the structure of pre-fusion rabies virus glycoprotein complexed with two protective antibodies, showing how they stabilize the protein and provide insights for vaccine design.

Identification of site-specific evolutionary trajectories shared across human betacoronaviruses

The paper identifies site-specific evolutionary trajectories shared across human betacoronaviruses by analyzing mutations and positive selection in four viruses.

Impact of the B.1.1.7 variant on neutralizing monoclonal antibodies recognizing diverse epitopes on SARS-CoV-2 Spike

This study examines how mutations in the B.1.1.7 variant of SARS-CoV-2 affect neutralization by monoclonal antibodies targeting non-RBD epitopes.

Molecular rationale for hantavirus neutralization by a reservoir host-derived monoclonal antibody

This study investigates how a monoclonal antibody neutralizes hantaviruses by targeting the glycoprotein lattice, revealing structural insights into antibody binding and its impact on viral entry.

Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

This study identifies vulnerabilities in coronavirus glycan shields by showing that MERS S protein has under-processed oligomannose-type glycan clusters, unlike SARS and HKU1 CoVs, and that these glycans do not form an effective shield against antibodies.

Parallel Evolution in the Emergence of Highly Pathogenic Avian Influenza A Viruses

This study identifies parallel mutations in avian influenza viruses associated with high pathogenicity using phylogenetic and statistical methods.

A key region of molecular specificity orchestrates unique ephrin-B1 utilization by Cedar virus

This study identifies a key molecular region in Cedar virus glycoprotein that determines its unique utilization of ephrin-B1 as an entry receptor, distinct from other HNVs.

Characterisation of antigenic MHC Class I-restricted T cell epitopes in the glycoprotein of Ebolavirus

This paper identifies nine T cell epitopes in the Ebolavirus glycoprotein and shows they are presented by multiple HLA alleles, suggesting broad immune recognition.

Molecular evolution, diversity and adaptation of H7N9 influenza A viruses in China

The paper analyzes the evolution and adaptation of H7N9 influenza viruses in China, identifying lineage-specific mutations and high-pathogenicity strains.