Negative feedback by NUR77/Nr4a1 restrains B cell clonal dominance during early T-dependent immune responses
J. F. Brooks, C. Tan, J. L. Mueller, K. Hibiya, R. Hiwa, J. Zikherman
This study shows that NUR77/Nr4a1 negatively regulates B cell clonal dominance in early T-dependent immune responses to maintain diversity in the germinal center niche.
bioRxiv · Dec 25, 2020Immunology