J. F. Brooks

Validation of a murine proteome-wide phage display library for the identification of autoantibody specificities

This paper validates a murine proteome-wide PhIP-seq library to identify autoantibody specificities in autoimmune disease models.

Molecular basis for potent B cell responses to antigen displayed on particles of viral size

This study identifies the molecular mechanisms by which particulate antigens induce potent B cell responses, showing signal amplification and reduced proliferation thresholds independent of T cell help and BCR avidity.

Negative feedback by NUR77/Nr4a1 restrains B cell clonal dominance during early T-dependent immune responses

This study shows that NUR77/Nr4a1 negatively regulates B cell clonal dominance in early T-dependent immune responses to maintain diversity in the germinal center niche.

A negative feedback loop mediated by the NR4A family of nuclear hormone receptors restrains expansion of B cells that receive signal one in the absence of signal two

This study identifies a negative feedback loop involving NR4A receptors that limits B cell proliferation without T cell help and enhances antibody responses to T-independent antigens.

Peripheral tolerance checkpoints imposed by ubiquitous antigen expression limit antigen-specific B-cell responses under strongly immunogenic conditions

The paper investigates how peripheral tolerance checkpoints limit self-reactive B-cell responses during bystander inflammation using a strong adjuvant and new detection tools.

Transfer of antigen-encoding bone marrow under immune-preserving conditions deletes mature antigen-specific B cells in recipients and inhibits antigen-specific antibody production

Natural strain variation reveals diverse biofilm regulation in squid-colonizing Vibrio fischeri

This study examines natural variation in V. fischeri isolates to reveal diverse biofilm regulation mechanisms during squid colonization, showing that while Syp biofilm is essential, regulatory pathways differ across evolutionary groups.