Author

R. Hiwa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

J. L. Mueller· 3 shared J. Zikherman· 3 shared C. Tan· 2 shared J. F. Brooks· 2 shared K. Hibiya· 2 shared A. Marson· 1 shared C. Heyn· 1 shared H. V. Nielsen· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersImmunology

J. L. Mueller

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3 papers

Recent·Most cited

Regulation of layered T cell tolerance mechanisms by the NR4A family is essential to preserve immune homeostasis and suppress autoimmunity

R. Hiwa, H. V. Nielsen, J. L. Mueller, J. Zikherman

This study shows that NR4A family members are essential for multiple T cell tolerance mechanisms, preventing autoimmunity even when Tregs are intact.

bioRxiv · Apr 28, 2021Immunology

Negative feedback by NUR77/Nr4a1 restrains B cell clonal dominance during early T-dependent immune responses

J. F. Brooks, C. Tan, J. L. Mueller, K. Hibiya, R. Hiwa, J. Zikherman

This study shows that NUR77/Nr4a1 negatively regulates B cell clonal dominance in early T-dependent immune responses to maintain diversity in the germinal center niche.

bioRxiv · Dec 25, 2020Immunology

A negative feedback loop mediated by the NR4A family of nuclear hormone receptors restrains expansion of B cells that receive signal one in the absence of signal two

C. Tan, R. Hiwa, J. L. Mueller, V. Vykunta, K. Hibiya, M. Noviski, J. Huizar, J. F. Brooks, J. Garcia, C. Heyn, Z. Li, A. Marson, J. Zikherman

This study identifies a negative feedback loop involving NR4A receptors that limits B cell proliferation without T cell help and enhances antibody responses to T-independent antigens.

bioRxiv · Mar 31, 2020Immunology