A negative feedback loop mediated by the NR4A family of nuclear hormone receptors restrains expansion of B cells that receive signal one in the absence of signal two
C. Tan, R. Hiwa, J. L. Mueller, V. Vykunta, K. Hibiya, M. Noviski, J. Huizar, J. F. Brooks, J. Garcia, C. Heyn, Z. Li, A. Marson, J. Zikherman
This study identifies a negative feedback loop involving NR4A receptors that limits B cell proliferation without T cell help and enhances antibody responses to T-independent antigens.
bioRxiv · Mar 31, 2020Immunology