E. D. Abel

ATF4 Expression in Thermogenic Adipocytes is Required for Cold-Induced Thermogenesis in Mice via FGF21-Independent Mechanisms

This study shows ATF4 is essential for cold-induced thermogenesis in mice through amino acid metabolism, independent of FGF21, while FGF21 is not required for thermoregulation.

GDF15 Is Required for Cold-Induced Thermogenesis and Contributes to Improve Systemic Metabolic Health Following Loss of OPA1 in Brown Adipocytes

This study identifies GDF15 as a mediator of improved metabolic health and thermogenesis in OPA1-deficient brown adipocytes, showing its role in glucose homeostasis and cold-induced thermogenesis.

Endosomal GLUT3 is essential for alternative macrophage signaling, polarization, and function

This study shows GLUT3 is essential for M2 macrophage polarization and function by regulating endosomal IL-4/STAT6 signaling.

Cardiac MAO-A inhibition protects against catecholamine-induced ventricular arrhythmias via enhanced diastolic calcium control

This study shows that inhibiting MAO-A in cardiomyocytes reduces arrhythmias by improving diastolic calcium control following catecholamine stress.

ATF4 Dependent Increase in Mitochondrial-Endoplasmic Reticulum Tethering Following OPA1 Deletion in Skeletal Muscle

This study shows that OPA1 deficiency in skeletal muscle increases MERC formation via ATF4, affecting calcium exchange and mitochondrial-ER tethering.

Metabolic rescue ameliorates mitochondrial encephalo-cardiomyopathy in murine and human iPSC models of Leigh syndrome

This study shows that metabolic rescue with nicotinamide riboside improves mitochondrial encephalo-cardiomyopathy in mouse and human iPSC models of Leigh syndrome.

Systematic Transmission Electron Microscopy-Based Identification and 3D Reconstruction of Cellular Degradation Machinery

This paper describes methods to identify and distinguish subcellular structures involved in macroautophagy using TEM and 3D reconstruction, with applications to quantify degradation machinery under different conditions.

Practices for Measuring 3D Organelle Morphology and Generating Surfaces with Amira

The paper introduces a standardized protocol using Amira software to quantify 3D organelle morphology from SBF-SEM data, demonstrating its application to mitochondria and ER structures.

A comprehensive approach for artifact-free sample preparation and assessment of mitochondrial morphology in tissue and cultured cells

This paper presents a method for preserving and quantitatively measuring mitochondrial morphology in tissues and cultured cells without introducing artifacts.

A Universal Approach to Analyzing Transmission Electron Microscopy with ImageJ

This paper introduces a standardized method using ImageJ to quantify subcellular organelle morphology in TEM images, focusing on mitochondria, ER, lysosomes, and autophagosomes.

Cardiac Specific Overexpression of Transcription Factor EB (TFEB) in Normal Hearts Induces Pathologic Cardiac Hypertrophy and Lethal Cardiomyopathy

This study shows that cardiac-specific overexpression of TFEB leads to pathologic hypertrophy and lethal cardiomyopathy through mitochondrial dysfunction and fibrosis.

OPA1 Deletion in Brown Adipose Tissue Improves Thermoregulation and Systemic Metabolism via FGF21

This study shows that deleting OPA1 in brown adipose tissue enhances thermoregulation and metabolism through the ATF4-FGF21 pathway, independent of thermogenesis.

SWELL1-LRRC8 complex regulates skeletal muscle cell size, intracellular signalling, adiposity and glucose metabolism

This study identifies the SWELL1-LRRC8 complex as a mechanosensor regulating skeletal muscle size, signaling, adiposity, and glucose metabolism through PI3K-AKT-mTOR pathways.