R. B. Dickinson

A predictive unifying explanation for nuclear shapes based on a simple geometric principle

This paper establishes a geometric principle explaining nuclear shapes based on surface area and volume constraints, showing that nuclear shape is determined by geometry rather than cytoskeletal forces.

Rho activation drives luminal collapse and eversion in epithelial acini

This study shows that RhoA activation causes apical-out eversion in epithelial acini by altering mechanical homeostasis and surface tension differences.

The nucleus bypasses obstacles by deforming like a drop with surface tension mediated by lamin A/C

The paper shows lamin A/C enables nuclear deformation through fibrous environments by acting like surface tension, allowing nuclei to bypass obstacles without rupturing.