Author

S. G. Mackintosh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:ChIP-seq· 1

Frequent Co-Authors

A. J. Gies· 1 shared A. J. Tackett· 1 shared A. Kannan· 1 shared A. Sobh· 1 shared B. F. Tan· 1 shared B. K. Das· 1 shared C. Aitken· 1 shared C. Espejo-Serrano· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCancer Biology

A. J. Gies

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Specific genomic targeting of the RNF12/RLIM E3 ubiquitin ligase selectively programmes developmental transcription

C. Espejo-Serrano, C. Aitken, B. F. Tan, D. G. May, R. J. Chrisopulos, K. J. Roux, S. G. Mackintosh, J. Gribnau, F. Bustos, C. Gontan, G. M. Findlay

This study identifies how RNF12/RLIM E3 ubiquitin ligase targets specific genomic regions to regulate gene expression through chromatin interactions and autoinhibitory mechanisms.

bioRxiv · Jun 14, 2023 · PreprintCell Biology

Piperlongumine (PL) conjugates induce targeted protein degradation

J. Pei, Y. Xiao, X. Liu, W. Hu, A. Sobh, Y. Yuan, S. Zhou, N. Hua, S. G. Mackintosh, X. Zhang, K. B. Basso, M. Kamat, Q. Yang, J. D. Licht, G. Zheng, , D. Lv

The paper identifies piperlongumine as a covalent E3 ligase recruiter that, when conjugated with CDK9 inhibitors, induces targeted protein degradation of CDK9 and EML4-ALK fusion oncoprotein.

bioRxiv · Jan 21, 2022Cancer Biology

Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton

H. Zhao, B. K. Das, L. Wang, T. Fujiwara, J. Zhou, N. Aykin-Burns, K. J. Krager, R. Lan, S. G. Mackintosh, R. Edmondson, M. L. Jennings, X. Wang, J. Q. Feng, T. Barrientos, J. Gogoi, , S. Mohan

This study shows that TFR1-mediated iron uptake in osteoclasts affects mitochondrial function and cytoskeleton, leading to increased bone mass in female mice.

bioRxiv · Sep 12, 2021Cell Biology

Methionine stress induces a ferroptotic gene signature in methionine dependent cancer cells

K. F. Wallis, J. T. Bird, A. J. Gies, S. G. Mackintosh, A. J. Tackett, S. Byrum, I. R. Miousse

The paper shows that methionine stress induces a ferroptotic gene signature in methionine-dependent cancer cells, which is reduced in methionine-independent cells.

bioRxiv · Aug 18, 2020 · PreprintCancer Biology