T. P. Lele

Dynamic Adaptation in Extant Porins Facilitates Antibiotic Tolerance in Energetic Escherichia coli

This study identifies a mechanism by which Escherichia coli tolerate antibiotics through dynamic porin inhibition, independent of gene expression, involving electrostatic modifications.

Nucleocytoplasmic transport rates are regulated by cellular processes that modulate GTP availability

The paper shows that changes in GTP availability, caused by cellular processes like migration, affect nucleocytoplasmic transport rates, impacting RNA export and protein synthesis.

A predictive unifying explanation for nuclear shapes based on a simple geometric principle

This paper establishes a geometric principle explaining nuclear shapes based on surface area and volume constraints, showing that nuclear shape is determined by geometry rather than cytoskeletal forces.

Rho activation drives luminal collapse and eversion in epithelial acini

This study shows that RhoA activation causes apical-out eversion in epithelial acini by altering mechanical homeostasis and surface tension differences.

The nucleus bypasses obstacles by deforming like a drop with surface tension mediated by lamin A/C

The paper shows lamin A/C enables nuclear deformation through fibrous environments by acting like surface tension, allowing nuclei to bypass obstacles without rupturing.

Reverse plasticity underlies rapid evolution by clonal selection within populations of fibroblastspropagated on a novel soft substrate

This study shows that reverse plasticity drives rapid evolution in fibroblasts adapted to soft substrates through genetic changes, not phenotypic plasticity alone.