Author

C. Y. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Assay:bulk RNA-seq· 4 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

B. C. Kennedy· 2 shared C. Willis· 2 shared D. R. Withers· 2 shared F. Gaspal· 2 shared G. Carlesso· 2 shared M. R. Clatworthy· 2 shared S. A. Hammond· 2 shared S. Dovedi· 2 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

B. C. Kennedy

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

An in silico framework for the rational design of vaginal probiotic therapy

C. Y. Lee, S. Bonakdar, K. B. Arnold

This paper develops an in silico framework to evaluate probiotic strain selection and dosing strategies for vaginal bacterial vaginosis, finding that adjunctive antibiotics and increased dosing frequency improve efficacy.

bioRxiv · Apr 10, 2024 · PreprintMicrobiology

Rapid establishment of a tumor-retained state curtails the contribution of conventional NK cells to anti-tumor immunity in solid cancers

I. W. Dean, C. Y. Lee, Z. K. Tuong, Z. Li, C. A. Tibbitt, C. Willis, F. Gaspal, B. C. Kennedy, V. Matei-Rascu, R. Fiancette, C. Nordenvall, U. Lindforss, S. M. Baker, C. Stockmann, V. Sexl, , D. R. Withers

This study shows that conventional NK cells rapidly lose effector functions upon entering tumors and that IL-15:IL-15Ra complexes can restore their function and tissue-residency.

bioRxiv · Aug 10, 2023Immunology

Time-, tissue- and treatment-associated heterogeneity in tumour-residing migratory DCs

C. Y. Lee, B. C. Kennedy, N. Richoz, I. Dean, Z. K. Tuong, F. Gaspal, Z. Li, C. Willis, T. Hasegawa, S. K. Whiteside, D. A. Posner, G. Carlesso, S. A. Hammond, S. Dovedi, R. Roychoudhuri, , M. R. Clatworthy

This study identifies heterogeneous tumor-residing migratory dendritic cells (mRegDCs) that show distinct transcriptional and functional profiles, impacting anti-tumor immune responses.

bioRxiv · Jul 3, 2023Immunology

Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralization

B. Wang, D. Asarnow, W.-H. Lee, C.-W. Huang, B. Faust, P. M. L. Ng, E. Z. X. Ngoh, M. Bohn, D. Bulkley, A. Pizzorno, H. C. Tan, C. Y. Lee, R. A. Minhat, O. Terrier, M. K. Soh, , C.-I. Wang

This study identifies a potent SARS-CoV-2 neutralizing antibody, 5A6, that binds bivalently to two RBDs on the spike protein, showing resistance to key mutations.

bioRxiv · Jul 14, 2020 · PreprintMicrobiology

Sporadic activation of an oxidative stress-dependent NRF2-p53 signaling network in breast epithelial spheroids and premalignancies

E. J. Pereira, J. S. Burns, C. Y. Lee, T. Marohl, D. Calderon, L. Wang, K. A. Atkins, C.-C. Wang, K. Janes

The paper identifies an oxidative stress-dependent NRF2-p53 signaling network in breast epithelial spheroids and premalignancies, showing its role in stress tolerance and 3D growth.

bioRxiv · Dec 5, 2019Cancer Biology

Metastatic function of METTL18 in breast cancer via actin methylation and Src

H. G. Kim, J. H. Kim, W. S. Yang, J. G. Park, Y. G. Lee, E. Kim, Y. H. Hong, M. Jo, C. Y. Lee, S. H. Kim, N. Y. Sung, Y.-S. Yi, Z. A. Ratan, S. Kim, B. C. Yoo, , J. Y. Cho

This study identifies METTL18 as an actin histidine methyltransferase that enhances breast cancer metastasis by promoting actin polymerization and Src activation.

bioRxiv · Nov 5, 2019 · PreprintCancer Biology

Zika virus infection preferentially counterbalances human peripheral monocyte and/or NK-cell activity

F. M. Lum, D. Lee, T.-K. Chua, J. J. Tan, C. Y. Lee, X. Liu, Y. Fang, B. Lee, W.-X. Yee, N. Rickett, P.-Y. Chia, V. Lim, Y.-S. Leo, D. Matthews, J. Hiscox, L. F. Ng

This study investigates how ZIKV infection affects monocyte and NK-cell activity through transcriptomic and immunoproteomic analyses, revealing counterbalancing effects on immune responses.

bioRxiv · Dec 5, 2017Immunology