K. K. Chan

An engineered ACE2 decoy receptor can be administered by inhalation and potently targets the BA.1 and BA.2 omicron variants of SARS-CoV-2

Machine learning guided design of high affinity ACE2 decoys for SARS-CoV-2 neutralization

The paper uses machine learning to design high-affinity ACE2 decoys for SARS-CoV-2 neutralization, identifying double mutants with binding affinity comparable to a previously known triple mutant.

Engineered High-Affinity ACE2 Peptide Mitigates ARDS and Death Induced by Multiple SARS-CoV-2 Variants

This study shows an engineered ACE2 peptide effectively mitigates ARDS and death in mice infected with multiple SARS-CoV-2 variants.

Clonally expanded CD38hi cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor-associated arthritis

This study identifies a distinct CD38hi cytotoxic CD8 T cell subset in ICI-induced arthritis, showing clonal expansion and IFN-driven activation.

An engineered decoy receptor for SARS-CoV-2 broadly binds protein S sequence variants

The paper tests an engineered decoy receptor's ability to bind SARS-CoV-2 variants and finds it remains effective against emerging mutations.