A. B. Malik

Endosomal Trafficking of Two Pore K+ Efflux Channel TWIK2 to Plasmalemma Mediates NLRP3 Inflammasome Activation and Inflammatory Injury

This study shows that TWIK2 channels are trafficked from endosomes to the plasma membrane via Rab11a in response to ATP, leading to K+ efflux and NLRP3 inflammasome activation, which can be inhibited to reduce inflammation.

An engineered ACE2 decoy receptor can be administered by inhalation and potently targets the BA.1 and BA.2 omicron variants of SARS-CoV-2

Engineered High-Affinity ACE2 Peptide Mitigates ARDS and Death Induced by Multiple SARS-CoV-2 Variants

This study shows an engineered ACE2 peptide effectively mitigates ARDS and death in mice infected with multiple SARS-CoV-2 variants.

Computer-Vision Stabilized Intravital Imaging Reveals Lung Capillary Neutrophil Dynamics Crucial for Lung Host-Defense Function

This study uses CASTii to analyze lung capillary neutrophil dynamics, revealing their role in host defense and response to infection.

Selective Nanotherapeutic Targeting of the Neutrophil Subset Mediating Inflammatory Injury

This study identifies a neutrophil subset responsible for ALI in sepsis and shows that targeting it with nanotherapeutics prevents ALI without harming host defense.

TAK1 Regulates Endothelial Integrity Through Stabilization of Junctions via GSK3β and FoxO1

This study identifies the TAK1-AKT-GSK3β-FoxO1 pathway as critical for maintaining endothelial barrier integrity and preventing vascular leak during sepsis.

EphB1 in Endothelial Cells Regulates Caveolae Formation and Endocytosis

This study shows that EphB1 in endothelial cells regulates caveolae formation and endocytosis by interacting with caveolin-1 and modulating Src-dependent phosphorylation.