J. Rehman

Impaired Barrier Integrity of the Skeletal Muscle Vascular Endothelium Drives Progression of Cancer Cachexia

This study identifies impaired vascular endothelial integrity in skeletal muscle as a driver of cancer cachexia and shows that restoring endothelial PGC1 can prevent muscle loss.

Matrimeres are systemic nanoscale mediators of tissue integrity and function

The paper identifies matrimeres as nanoscale mediators of tissue integrity, showing they can restore vascular integrity after injury and are reconstituted from fibronectin, DNA, and acidic conditions.

SenePy: Unveiling the Cell-Type Specific Landscape of Cellular Senescence through Single-Cell Analysis in Living Organisms

SenePy identifies cell-type specific senescence signatures from single-cell data, improving senescent cell detection in vivo and revealing increased senescence in diseases like COVID-19 and myocardial infarction.

Limited Diffusion of Scientific Knowledge Forecasts Collapse

The paper forecasts scientific knowledge collapse by analyzing diffusion patterns in biomedical research, showing limited diffusion predicts abrupt declines in popularity.

Parallel Activation of Src and Hif1α Increases Localized Glycolytic ATP Generation for Re-assembly of Endothelial Adherens Junctions

This study shows that Src and Hif1α activation increases glycolytic ATP production near endothelial adherens junctions, facilitating their re-assembly after injury.

Two-color live-cell STED nanoscopy by click labeling with cell-permeable fluorophores

This paper demonstrates two-color STED nanoscopy using organic fluorophores and click labeling for long-term imaging of living cells.

Pink1-mediated mitophagy in the endothelium releases proteins encoded by mitochondrial DNA and activates neutrophil responses

This study identifies endothelial mitophagy as a source of mitochondrial formyl proteins that activate neutrophils and contribute to lung inflammation.

An engineered ACE2 decoy receptor can be administered by inhalation and potently targets the BA.1 and BA.2 omicron variants of SARS-CoV-2

Engineered High-Affinity ACE2 Peptide Mitigates ARDS and Death Induced by Multiple SARS-CoV-2 Variants

This study shows an engineered ACE2 peptide effectively mitigates ARDS and death in mice infected with multiple SARS-CoV-2 variants.

Computer-Vision Stabilized Intravital Imaging Reveals Lung Capillary Neutrophil Dynamics Crucial for Lung Host-Defense Function

This study uses CASTii to analyze lung capillary neutrophil dynamics, revealing their role in host defense and response to infection.

Glycolysis Inhibition Regulates Endothelial Junctions by Perturbing Actin and Focal Adhesions

This study shows that glycolysis inhibition reduces VE-cadherin junction tension by disrupting actin and focal adhesions, impacting endothelial barrier integrity.

Detection of Viral RNA Fragments in Human iPSC-Cardiomyocytes following Treatment with Extracellular Vesicles from SARS-CoV-2 Coding-Sequence-Overexpressing Lung Epithelial Cells

This study shows that SARS-CoV-2 RNA can enter cardiomyocytes via extracellular vesicles from infected lung cells, leading to inflammation-related gene upregulation.