Author

K. McAndrews

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 3 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

R. Kalluri· 4 shared H. Sugimoto· 3 shared V. LeBleu· 3 shared A. M. Lopez· 1 shared A. M. Sockwell· 1 shared A. Maitra· 1 shared B. Li· 1 shared B. M. Moreno Diaz· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCancer Biology

R. Kalluri

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Single extracellular vesicle imaging and computational analysis identifiesinherent architectural heterogeneity

K. S. Kapoor, R. Kalluri, S. Kong, H. Sugimoto, W. Guo, V. Boominathan, Y.-L. Chen, S. L. Biswal, T. Terlier, K. McAndrews

The paper uses cryo-TEM and a segmentation model to analyze EV architecture, finding consistent structural heterogeneity across different sources and purification methods.

bioRxiv · Dec 11, 2023Bioengineering

Engineered immunomodulatory extracellular vesicles derived from epithelial cells acquire capacity for positive and negative T cell co-stimulation in cancer and autoimmunity

F. Kugeratski, V. LeBleu, D. Dowlatshahi, H. Sugimoto, K. Arian, Y. Fan, L. Huang, D. Wills, S. Lilla, K. Hodge, S. Zanivan, K. McAndrews, R. Kalluri

This study engineers extracellular vesicles from epithelial cells to express immunomodulatory proteins, showing they can induce both positive and negative T cell co-stimulation in cancer and autoimmunity.

bioRxiv · Nov 2, 2023 · PreprintCancer Biology

Oncogenic KrasG12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8+ T cells dependent manner

K. K. Mahadevan, K. McAndrews, V. LeBleu, S. Yang, H. Lyu, B. Li, A. M. Sockwell, M. L. Kirtley, S. J. Morse, B. M. Moreno Diaz, M. P. Kim, N. Feng, A. M. Lopez, P. A. Guerrero, H. Sugimoto, , R. Kalluri

This study shows that MRTX1133, a KrasG12D inhibitor, reduces early pancreatic lesions and, when combined with immunotherapy, regresses advanced PDAC by enhancing CD8+ T cell activity.

bioRxiv · Feb 15, 2023 · PreprintCancer Biology

Autophagy is associated with survival and resiliency of fibroblasts in long-term decaying post-mortem parenchymal tissue

K. McAndrews, D. J. McGrail, L. B. Gansmo, S. P. Y. Che, D. Chakravarti, V. LeBleu, R. Kalluri

This study shows fibroblasts survive longer in decaying post-mortem tissue and activate autophagy and lysosomal pathways to maintain viability.

bioRxiv · Aug 18, 2022 · PreprintCell Biology