A. J. Nelson

Lung-resident memory B cells maintain allergic IgE responses in the respiratory tract

This study identifies lung-resident memory B cells as a key source of allergen-specific IgE in the respiratory tract and shows their role in maintaining allergic asthma.

Automating UbiFast for High-throughput and Multiplexed Ubiquitin Enrichment

The paper automates the UbiFast method to enable high-throughput, multiplexed ubiquitylation profiling, identifying ~20,000 sites from 500 g input in ~2 hours with improved reproducibility and scalability.

High-Throughput Analysis of Lung Immune Cells in a Murine Model of Rheumatoid Arthritis-Associated Lung Disease

The paper analyzes lung immune cell populations in a murine RA model using single-cell RNA-seq and NanoString to identify gene expression patterns linked to RA-associated lung disease.

Molecular basis for substrate recruitment to the PRMT5 methylosome

The paper identifies a conserved peptide sequence in PRMT5 substrate adaptors that mediates their interaction with PRMT5 and shows its necessity for methylation of substrates like spliceosome, histones, and ribosome complexes.

Acetylation-mediated phase control of the nucleolus regulates cellular acetyl-CoA responses

The paper shows that acetyl-CoA depletion disrupts nucleolar integrity, activates p53 via ribosomal proteins, and is mediated by class IIa HDACs regulating nucleolar phase state.

CD36hi monocytes play immunoregulatory roles in human umbilical cord blood

This study identifies CD36hi monocytes in umbilical cord blood that generate Foxp3+ T cells with suppressive functions, distinct from adult regulatory T cells.