P. White

Norovirus NS3 protein induces apoptosis through translation repression and dysregulation of BCL-2 pro-survival proteins

This study identifies Norovirus NS3 protein as inducing apoptosis by repressing translation and dysregulating BCL-2 proteins, suggesting it as a potential antiviral target.

Development of SARS-CoV-2 mRNA vaccines encoding spike N-terminal and receptor binding domains

The paper develops and evaluates an mRNA vaccine, mRNA-1283, encoding SARS-CoV-2 spike N-terminal and receptor-binding domains, showing improved immunogenicity and protection against multiple variants in mice.

Siglec-5 is an inhibitory immune checkpoint molecule for human T cells

This study identifies Siglec-5 as an inhibitory checkpoint molecule on activated human T cells that suppresses TCR-mediated activation and effector functions.

Extrinsic motivators drive children's cooperation to conserve forests

This study shows that extrinsic motivators increase children's cooperation in forest conservation games across three countries.

Psychological stress disrupts intestinal epithelial cell function and mucosal integrity through microbe and host-directed processes

This study shows that psychological stress disrupts intestinal epithelial cell function and mucosal integrity in mice, mediated by microbiota and host stress signals.

A novel mechanism for the loss of mRNA activity in lipid nanoparticle delivery systems.

This study identifies an electrophilic impurity in lipid nanoparticles that modifies mRNA, rendering it untranslatable and reducing protein expression.

Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever

This study identifies SLC25A44 as a mitochondrial BCAA carrier essential for metabolic flexibility and optimal fever response through enhanced mitochondrial BCAA oxidation and thermogenesis.

Cooperative Communication with Humans Evolved to Emerge Early in Dogs

This study compares dog and wolf puppies to show domestication enhanced dogs' cooperative communication with humans through increased attraction to humans.

Inter-domain dynamics in the chaperone SurA and multi-site binding to its unfolded outer membrane protein clients

This study investigates the conformational dynamics of SurA and its interaction with unfolded OMP clients using multiple biophysical techniques.

Mouse Norovirus infection arrests host cell translation uncoupled from the stress granule-PKR-eIF2α axis

This study shows that mouse norovirus infection suppresses host translation and cytokine production while promoting viral replication by recruiting G3BP1 to block stress granule formation.

CD36hi monocytes play immunoregulatory roles in human umbilical cord blood

This study identifies CD36hi monocytes in umbilical cord blood that generate Foxp3+ T cells with suppressive functions, distinct from adult regulatory T cells.