CtBP restricts DUX-dependent and -independent genetic program for the 2-cell-like state in murine embryonic stem cells
K. Yoshioka, K. Sugiyama, M. Ichisakino, S. A. Abadi, N. Hayakawa, M. Marutani, R. Masuda, K. Takahashi, Y. Seki
The paper shows that Ctbp1/2 disruption activates DUX-dependent and -independent pathways in mESCs, leading to 2-cell-like state features through PRAMEL7 upregulation.
bioRxiv · Jan 12, 2024Cell Biology