Author

A. D. Attie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Research Focus:metabolism & bioenergetics· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

M. P. Keller· 5 shared K. L. Schueler· 3 shared D. J. Pagliarini· 2 shared E. Shishkova· 2 shared J. J. Coon· 2 shared N. M. Niemi· 2 shared A. Bradley· 1 shared A. C. Powers· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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5 shared papersCell Biology

M. P. Keller

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue

D. J. Duerre, J. K. Hansen, S. John, A. Jen, N. Carrillo, H. Bui, Y. Bao, M. Fabregat, K. Overmyer, E. Shishkova, M. P. Keller, R. A. Anderson, V. L. Cryns, A. D. Attie, J. Coon, , A. Galmozzi

This study shows that heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue by affecting UCP1 and mitochondrial function.

bioRxiv · Nov 28, 2023 · PreprintCell Biology

Pancreatic islet α cell function and proliferation requires the arginine transporter SLC7A2

E. Spears, J. E. Stanley, M. Shou, C. Dai, A. Bradley, L. Yin, X. Li, K. Sellick, G. Poffenberger, K. C. Coate, S. D. Shrestha, R. Jenkins, K. Sloop, K. T. Wilson, A. D. Attie, , E. D. Dean

This study identifies SLC7A2 as essential for α cell proliferation and glucagon secretion, linking arginine transport to metabolic regulation and HbA1c variation.

bioRxiv · Aug 10, 2023Physiology

Pptc7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy

N. M. Niemi, L. R. Serrano, L. K. Muehlbauer, C. Balnis, K.-L. Kozul, E. H. Rashan, E. Shishkova, K. L. Schueler, M. P. Keller, A. D. Attie, J. Pagan, J. J. Coon, D. J. Pagliarini

This study shows that Pptc7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy, leading to metabolic defects and early lethality in mice.

bioRxiv · Feb 28, 2023Biochemistry

Novel regulators of islet function identified from genetic variation in mouse islet Ca2+ oscillations

C. Emfinger, L. E. Clark, B. S. Yandell, K. L. Schueler, S. Simonett, D. S. Stapleton, K. Mitok, M. J. Merrins, M. P. Keller, A. D. Attie

The paper identifies novel regulators of islet Ca2+ oscillations and insulin secretion by integrating genetic variation, Ca2+ dynamics, and protein abundance in mouse islets with human GWAS data.

bioRxiv · Nov 26, 2022 · PreprintBiochemistry

Coding variants identified in diabetic patients alter PICK1 BAR domain function in insulin granule biogenesis

R. C. Andersen, M. D. Lycas, J. H. Schmidt, N. R. Christensen, V. K. Lund, J. Rombach, M. Stoklund, D. Stapleton, G. Noes-Holt, M. P. Keller, A. M. Jansen, R. Herlo, O. Kjaerulff, B. Holst, A. D. Attie, , k. L. Madsen

The paper identifies coding variants in PICK1 that impair its BAR domain function, leading to altered insulin granule biogenesis in diabetic patients.

bioRxiv · Oct 5, 2020Cell Biology

Pptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis

N. M. Niemi, G. M. Wilson, K. A. Overmyer, F.- N. Vogtle, D. C. Lohman, K. L. Schueler, A. D. Attie, C. Meisinger, J. J. Coon, D. J. Pagliarini

This study shows that Pptc7 is essential for mitochondrial metabolism and biogenesis, as its deletion in mice causes metabolic defects and early death.

bioRxiv · Sep 25, 2018Biochemistry