M. P. Keller

Quantitative trait loci mapping identifies genetic loci modifying MafAS64F-mediated dysglycemia

This study maps quantitative trait loci modifying glycemia in MafAS64F-driven dysglycemia using genetically diverse mice.

Heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue

This study shows that heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue by affecting UCP1 and mitochondrial function.

Pancreatic islet α cell function and proliferation requires the arginine transporter SLC7A2

This study identifies SLC7A2 as essential for α cell proliferation and glucagon secretion, linking arginine transport to metabolic regulation and HbA1c variation.

Pptc7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy

This study shows that Pptc7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy, leading to metabolic defects and early lethality in mice.

Novel regulators of islet function identified from genetic variation in mouse islet Ca2+ oscillations

The paper identifies novel regulators of islet Ca2+ oscillations and insulin secretion by integrating genetic variation, Ca2+ dynamics, and protein abundance in mouse islets with human GWAS data.

Coding variants identified in diabetic patients alter PICK1 BAR domain function in insulin granule biogenesis

The paper identifies coding variants in PICK1 that impair its BAR domain function, leading to altered insulin granule biogenesis in diabetic patients.