Author

K. M. Irvine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

D. A. Hume· 3 shared A. R. Pettit· 2 shared A. Sehgal· 2 shared H. Ebersbach· 2 shared L. Batoon· 2 shared O. L. Patkar· 2 shared S. Keshvari· 2 shared A. C. Perkins· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersImmunology

D. A. Hume

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4 papers

Recent·Most cited

Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic metabolism to fuel growth.

S. Kesvari, J. Masson, M. Ferrari-Cestari, L.-G. Bodea, F. Nooru-Mohamed, B. Tse, K. Sokolowski, L. Batoon, O. Patkar, M. Sullivan, H. Ebersbach, C. Stutz, R. Parton, A. Pettit, D. Hume, K. M. Irvine

This study shows that CSF1 increases tissue macrophages and alters systemic metabolism, including glucose uptake and fat mobilization, with reversible effects on liver size and body composition.

bioRxiv · May 17, 2023 · PreprintImmunology

Intraperitoneal transfer of wild-type bone marrow cells in the Csf1r knockout rat repopulates resident tissue macrophages without contributing to monocytopoiesis.

A. Sehgal, D. Cater-Cusack, S. Keshvari, O. L. Patkar, S. Huang, K. Summers, K. M. Irvine, D. A. Hume

The paper shows that wild-type bone marrow cells can repopulate tissue macrophages in Csf1r knockout rats without contributing to monocytopoiesis.

bioRxiv · Feb 19, 2023 · PreprintImmunology

Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease

S. Keshvari, B. Genz, N. Teakle, M. Caruso, M. F. Cestari, O. L. Patkar, B. W. Tse, K. A. Sokolowski, H. Ebersbach, J. Jascur, K. P. MacDonald, G. Miller, G. A. Ramm, A. R. Pettit, A. D. Clouston, , K. M. Irvine

This study shows that CSF1-Fc treatment promotes liver regeneration and resolves advanced fibrosis in mice with chronic liver injury.

bioRxiv · Nov 7, 2021Immunology

Fragmentation of macrophages during isolation confounds analysis of single cell preparations from mouse hematopoietic tissues

S. M. Millard, O. Heng, K. S. Opperman, A. Sehgal, K. M. Irvine, S. Kaur, K. M. Summers, C. J. Sandrock, A. C. Wu, G. W. Magor, L. Batoon, A. C. Perkins, J. E. Noll, A. C. Zannettino, D. P. Sester, , A. R. Pettit

The paper identifies macrophage fragmentation during isolation as a confounding factor in single-cell analysis of mouse hematopoietic tissues, revealing its impact on marker expression and function.

bioRxiv · Apr 28, 2021Immunology