Author

D. A. Hume

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. R. Pettit· 3 shared A. Sehgal· 3 shared K. M. Irvine· 3 shared A. C. Wu· 2 shared J.-P. Levesque· 2 shared K. Summers· 2 shared L. Batoon· 2 shared L. J. Raggatt· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersImmunology

A. R. Pettit

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Author profile →

6 papers

Recent·Most cited

Intraperitoneal transfer of wild-type bone marrow cells in the Csf1r knockout rat repopulates resident tissue macrophages without contributing to monocytopoiesis.

A. Sehgal, D. Cater-Cusack, S. Keshvari, O. L. Patkar, S. Huang, K. Summers, K. M. Irvine, D. A. Hume

The paper shows that wild-type bone marrow cells can repopulate tissue macrophages in Csf1r knockout rats without contributing to monocytopoiesis.

bioRxiv · Feb 19, 2023 · PreprintImmunology

Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease

S. Keshvari, B. Genz, N. Teakle, M. Caruso, M. F. Cestari, O. L. Patkar, B. W. Tse, K. A. Sokolowski, H. Ebersbach, J. Jascur, K. P. MacDonald, G. Miller, G. A. Ramm, A. R. Pettit, A. D. Clouston, , K. M. Irvine

This study shows that CSF1-Fc treatment promotes liver regeneration and resolves advanced fibrosis in mice with chronic liver injury.

bioRxiv · Nov 7, 2021Immunology

Fragmentation of macrophages during isolation confounds analysis of single cell preparations from mouse hematopoietic tissues

S. M. Millard, O. Heng, K. S. Opperman, A. Sehgal, K. M. Irvine, S. Kaur, K. M. Summers, C. J. Sandrock, A. C. Wu, G. W. Magor, L. Batoon, A. C. Perkins, J. E. Noll, A. C. Zannettino, D. P. Sester, , A. R. Pettit

The paper identifies macrophage fragmentation during isolation as a confounding factor in single-cell analysis of mouse hematopoietic tissues, revealing its impact on marker expression and function.

bioRxiv · Apr 28, 2021Immunology

Serum CSF1 levels are elevated in patients following partial hepatectomy and acetaminophen induced acute liver failure: Reanalysis of previous data

B. Stutchfield, P. Starkey Lewis, S. Wigmore, K. Simpson, D. A. Hume, S. J. Forbes

This study reanalyzes previous data showing elevated serum CSF1 levels after partial hepatectomy and in ALF patients, with higher levels in non-survivors.

bioRxiv · Apr 2, 2021 · PreprintImmunology

Stable colony stimulating factor 1 fusion protein treatment increases HSC pool and enhances their mobilisation in mice.

S. Kaur, A. Sehgal, A. C. Wu, S. M. Millard, L. Batoon, M. Ferrari-Cestari, J.-P. Levesque, D. A. Hume, L. J. Raggatt, A. R. Pettit

CSF1-Fc treatment expands the HSC pool and enhances their mobilization in mice, improving transplantation outcomes.

bioRxiv · Sep 13, 2020Cell Biology

Transcriptional network analysis of transcriptomic diversity in resident tissue macrophages and dendritic cells in the mouse mononuclear phagocyte system.

K. Summers, S. J. Bush, D. A. Hume

The paper analyzes transcriptomic diversity in mouse mononuclear phagocyte system cells using RNA-seq data, finding that surface markers poorly define subpopulations and that co-expression patterns reveal functional clusters.

bioRxiv · Mar 24, 2020Immunology