Author

A. Haluck-Kangas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 2 Approach:wet-lab / biochemical assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

M. E. Peter· 3 shared A. A. Sarshad· 2 shared A. E. Murmann· 2 shared E. T. Bartom· 2 shared M. Hafner· 2 shared M. Patel· 2 shared Q. Q. Gao· 2 shared W. Putzbach· 2 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCancer Biology

M. E. Peter

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4 papers

Recent·Most cited

CD95/Fas ligand mRNA is toxic to cells through more than one mechanism

A. Haluck-Kangas, M. Fink, E. T. Bartom, M. E. Peter

This study shows CD95L mRNA induces toxicity through multiple mechanisms, including DISE and Ago-dependent RNAi, with varying dependence on Ago proteins across cell lines.

bioRxiv · Oct 3, 2022Cell Biology

CD95/Fas ligand mRNA is toxic to cells

W. Putzbach, A. Haluck-Kangas, Q. Q. Gao, A. A. Sarshad, E. T. Bartom, A. M. Stults, A. S. Qadir, M. Hafner, M. E. Peter

The paper shows that full-length CD95L mRNA is toxic to cells and induces apoptosis through sRNA processing independent of Dicer and Drosha, suggesting a new role for RNAi in cell fate regulation.

bioRxiv · Sep 14, 2018Cancer Biology

Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism

W. Putzbach, Q. Q. Gao, M. Patel, S. van Dongen, A. Haluck-Kangas, A. A. Sarshad, E. Bartom, K.-Y. A. Kim, D. M. Scholtens, M. Hafner, J. C. Zhao, A. E. Murmann, M. E. Peter

The paper shows that many si/shRNAs targeting CD95 or CD95L induce cancer cell death via an off-target mechanism called DISE by eliminating survival genes.

bioRxiv · Sep 14, 2017Cancer Biology

Induction of DISE in ovarian cancer cells in vivo

A. E. Murmann, K. M. McMahon, A. Haluck-Kangas, N. Ravindran, M. Patel, C. Law, S. Brockway, J.-J. Wei, C. S. Thaxton, M. Peter

This study shows that DISE can be induced in ovarian cancer cells in vivo using siRNA-TLPs, leading to tumor growth reduction.

bioRxiv · Sep 10, 2017Cancer Biology