K. M. Schmoller

A Multiparametric Analysis Reveals Differential Behavior of Spheroid Cultures on Distinct Ultra-Low Attachment Plates Types

This study compares spheroid formation and behavior across six ultra-low attachment plate types using four human cell lines, finding size and eccentricity differences that suggest plate type impacts experimental outcomes.

A novel genetic fluorescent reporter to visualize mitochondrial nucleoids

The paper introduces a genetic fluorescent reporter, mt-HI-NESS, to visualize mitochondrial nucleoids in live cells without affecting mtDNA replication or expression.

An mTOR/RNA pol I axis shapes chromatin architecture in response to fasting

This study shows fasting induces large-scale chromatin reorganization in C. elegans, requiring mTOR inhibition and RNA Pol I activity.

Decoupling of transcript and protein concentrations ensures budding yeast histone homeostasis in different nutrient conditions

This study shows budding yeast maintains histone homeostasis by decoupling transcript and protein abundance under different nutrient conditions.

Regulation with cell size ensures mitochondrial DNA homeostasis during cell growth

The paper shows that mitochondrial DNA copy number increases with cell volume in budding yeast through nuclear-encoded factors, maintaining stable concentrations without cell-cycle regulation.

Cell-ACDC: a user-friendly toolset embedding state-of-the-art neural networks for segmentation, tracking and cell cycle annotations of live-cell imaging data

Cell-ACDC provides a user-friendly toolset for segmentation, tracking, and cell cycle annotation of live-cell imaging data using deep learning models.

Size-independent mRNA synthesis and chromatin-based partitioning mechanisms generate and maintain constant amounts of protein per cell

The paper identifies transcriptional and chromatin-based mechanisms that generate and maintain constant protein amounts per cell despite changes in cell size.