Author

K. Machaca

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 2 Assay:imaging· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

F. Yu· 4 shared A. S. Hammad· 3 shared L. Assaf· 2 shared M. Fisher· 2 shared M. Terasaki· 2 shared R. Courjaret· 2 shared A. A. Elmi· 1 shared A. Elmi· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersCell Biology

F. Yu

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Author profile →

5 papers

Recent·Most cited

Architecture of Ca2+ tunneling, a basic Ca2+ signaling modality important for secretion

R. Courjaret, L. E. Wagner, R. R. Ammouri, L. Assaf, F. Yu, M. Fisher, M. Terasaki, D. I. Yule, K. Machaca

This study outlines the architecture of Ca2+ tunneling, a Ca2+ signaling modality, and shows it is important for Cl- secretion in sweat glands.

bioRxiv · Dec 17, 2023 · PreprintCell Biology

Progesterone induces meiosis through two obligate co-receptors with PLA2 activity

N. Nader, L. Assaf, L. Zarif, A. Halama, S. Yadav, M. Dib, N. Attarwala, Q. Chen, K. Suhre, S. S. Gross, K. Machaca

This study identifies ABHD2 as an essential co-receptor for mPRβ to trigger meiosis via PLA2 activity in Xenopus oocytes.

bioRxiv · Sep 9, 2023Cell Biology

ER-Mitochondria Contact Sites expand during mitosis

F. Yu, R. Courjaret, A. Elmi, A. S. Hammad, M. Fisher, M. Terasaki, K. Machaca

The paper shows that ER-mitochondria contact sites expand during mitosis, enhancing Ca2+ coupling and mitochondrial activation to meet increased energy demands.

bioRxiv · Jun 22, 2023Cell Biology

STIM1 signals through NFAT independently of Orai1 and SOCE to regulate breast cancer cell migration

A. S. Hammad, F. Yu, F. D. Horgen, K. Machaca

The paper shows that STIM1 knockout in breast cancer cells increases migration and invasion due to NFATC2 downregulation, independent of SOCE and Ca2+ entry.

bioRxiv · Oct 23, 2022 · PreprintCell Biology

Phosphorylation of STIM1 at ERK/CDK sites is dispensable for cell migration and ER partitioning in mitosis

A. S. Hammad, F. Yu, W. Botheju, A. A. Elmi, E. Alcantara-Adap, K. Machaca

This study shows that STIM1 phosphorylation at ERK/CDK sites is not required for SOCE, cell migration, or ER partitioning during mitosis.

bioRxiv · Jul 6, 2021Cell Biology