M. Fisher

Targeting of a STING Agonist to Perivascular Macrophages in Prostate Tumors Delays Resistance to Androgen Deprivation Therapy

This study shows targeting a STING agonist to perivascular macrophages in ADT-treated prostate tumors delays castration resistance prostate cancer onset.

S1 hydrophobic residues modulate voltage sensing phosphatase enzymatic function and voltage sensing

This study shows that S1 hydrophobic residues in voltage sensing phosphatase (VSP) modulate voltage sensing and enzymatic activity by altering voltage dependence and kinetics.

Architecture of Ca2+ tunneling, a basic Ca2+ signaling modality important for secretion

This study outlines the architecture of Ca2+ tunneling, a Ca2+ signaling modality, and shows it is important for Cl- secretion in sweat glands.

Invasive European green crab (Carcinus maenas) predation revealed with quantitative DNA metabarcoding

The paper uses DNA metabarcoding to analyze the diet of invasive European green crabs and finds significant differences in prey composition between aquaculture and natural habitats.

Determining the microbial species content in tissue from Alzheimer's and Parkinson's Disease patients

This study develops a nanopore sequencing method to detect fungal DNA in brain tissue and CSF from Alzheimer's and Parkinson's Disease patients, revealing fungal presence in healthy and diseased samples.

ER-Mitochondria Contact Sites expand during mitosis

The paper shows that ER-mitochondria contact sites expand during mitosis, enhancing Ca2+ coupling and mitochondrial activation to meet increased energy demands.

Landscape-scale exposure to multiazole-resistant Aspergillus fumigatus bioaerosols

UK-wide citizen science surveillance finds a ubiquitous exposure to aerosolized spores of a human fungal pathogen that have evolved cross-resistance to essential clinical antifungal drugs.

Human HelQ and DNA polymerase δ interact to halt DNA synthesis and stimulate DNA single-strand annealing

This study shows HelQ interacts with DNA polymerase δ to stop DNA synthesis and enhance DNA single-strand annealing during repair.

Semi-automated protocol to quantify and characterize fluorescent three-dimensional vascular images

The paper describes a semi-automated protocol to quantify and characterize 3D vascular images in mouse tissues, achieving 80% sensitivity and 90% specificity in automated segmentation.

Rhamnan Sulfate Reduces Atherosclerotic Plaque Formation and Vascular Inflammation

This study shows rhamnan sulfate reduces atherosclerosis and vascular inflammation in ApoE-/- mice by enhancing endothelial barrier function and inhibiting NF-κB pathway activation.

Evolution of Knockdown Resistance Haplotypes in Response to Pyrethroid Selection in Aedes aegypti

This study tracks the evolution of kdr haplotypes in Aedes aegypti over 18 years in Iquitos, Peru, showing a direct link between pyrethroid spraying and increased resistance allele frequencies.

β-Coronaviruses use lysosomal organelles for cellular egress.

This study shows β-coronaviruses exit cells via lysosomal trafficking, not the secretory pathway, and identifies Arl8b as a regulator of this process.

Tissue-specific changes in size and shape of the ligaments and tendons of the porcine knee during post-natal growth

This study examines growth patterns of ligaments and tendons in pig knees, finding varying growth rates and allometric trends among tissues.

Microbiome and Antimicrobial Resistance Gene Dynamics in International Travelers

This study uses metagenomic sequencing to track changes in gut microbiota and antimicrobial resistance genes in international travelers, finding increased resistance genes and Escherichia species without affecting microbial diversity.