Author

L. E. Wagner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Approach:experimental assay· 5 Organism:mouse· 3 Assay:imaging· 2 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

D. I. Yule· 5 shared V. Arige· 3 shared L. E. Terry· 2 shared D. L. Gill· 1 shared F. Yu· 1 shared G. Fan· 1 shared H. Bagavant· 1 shared I. I. Serysheva· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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5 shared papersPhysiology

D. I. Yule

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5 papers

Recent·Most cited

Dysregulated Ca2+ signaling, fluid secretion, and mitochondrial function in a mouse model of early Sjogrens syndrome

K.-T. Huang, L. E. Wagner, T. Takano, X.-X. Lin, H. Bagavant, U. Deshmukh, D. I. Yule

This study identifies dysregulated Ca2+ signaling and mitochondrial dysfunction in a mouse model of early Sjogrens syndrome, leading to reduced fluid secretion.

bioRxiv · Mar 19, 2024Physiology

Architecture of Ca2+ tunneling, a basic Ca2+ signaling modality important for secretion

R. Courjaret, L. E. Wagner, R. R. Ammouri, L. Assaf, F. Yu, M. Fisher, M. Terasaki, D. I. Yule, K. Machaca

This study outlines the architecture of Ca2+ tunneling, a Ca2+ signaling modality, and shows it is important for Cl- secretion in sweat glands.

bioRxiv · Dec 17, 2023 · PreprintCell Biology

Functional Determination of Calcium Binding Sites Required for the Activation of Inositol 1,4,5-trisphosphate receptors.

V. Arige, L. E. Terry, L. E. Wagner, M. R. Baker, G. Fan, I. I. Serysheva, D. I. Yule

This study identifies acidic residues in IP3Rs critical for Ca2+ binding and activation, showing their role in modulating channel activity and Ca2+ sensitivity.

bioRxiv · Mar 7, 2022Physiology

CREB regulates the expression of Type 1 Inositol 1,4,5-trisphosphate receptors

V. Arige, L. E. Terry, T. R. Knebel, L. E. Wagner, D. I. Yule

This study shows that CREB regulates IP3R1 expression and localization, affecting Ca2+ release and puffs.

bioRxiv · May 5, 2021Physiology

Omnitemporal choreographies of IP3R and all five STIM/Orai underlie the complexity of mammalian Ca2+ signaling

S. M. Emrich, R. E. Yoast, P. Xin, V. Arige, L. E. Wagner, N. Hempel, D. L. Gill, J. Sneyd, D. I. Yule, M. Trebak

This paper shows that all five STIM1/2 and Orai1/2/3 isoforms, along with IP3R, work together in a graded manner to ensure precise and diverse Ca2+ signaling in mammals.

bioRxiv · Oct 4, 2020Physiology