K. Mackie

Brain Organoid Computing for Artificial Intelligence

The paper develops Brainoware, a living AI hardware using 3D brain organoids to compute nonlinear equations and demonstrate learning capabilities.

Plasma and liver lipids are differentially regulated after cannabinoid treatments in male and female mice

This study examines sex differences in cannabinoid and endolipid regulation in male and female mice after CBD, THC, or THC+CBD treatment, showing distinct plasma and liver responses.

Engineering human spinal microphysiological systems to model opioid-induced tolerance

This paper develops human spinal microphysiological systems to model opioid-induced tolerance and hyperalgesia, showing altered neural activity and receptor downregulation with prolonged opioid exposure.

Cannabinoids accumulate in mouse breast milk and differentially regulate lipid signaling molecules involved in infant development

This study shows cannabinoids accumulate in mouse breast milk and alter lipid signaling molecules in pups.

Cannabidiol reduces the latency for the behavioral effect of escitalopram in chronically stressed mice: involvement of NAPE-PLD expressed in parvalbumin-positive interneurons and the prefrontal cortex.

This study shows that CBD reduces the latency of escitalopram's anti-stress effects in chronically stressed mice, involving NAPE-PLD in the prefrontal cortex and parvalbumin interneurons.

Controllable Fusion of Human Brain Organoids Using Acoustofluidics

This paper develops an acoustofluidic method to controllably fuse human brain organoids, enhancing standardization and reproducibility of fused models.

One-stop Microfluidic Assembly of Human Brain Organoids to Model Prenatal Cannabis Exposure

This paper develops a microfluidic platform to assemble human brain organoids and models prenatal cannabis exposure effects on early brain development.