Author

Z. Ao

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 7 Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 12 Organism:human· 6 Research Focus:cell type annotation· 5 Organism:mouse· 5 Assay:organoid / primary culture· 5 Research Focus:drug response / drug discovery· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:cell-cell communication· 3

Frequent Co-Authors

F. Guo· 7 shared H. Cai· 7 shared Z. Wu· 6 shared X. Yao· 5 shared D. Kobasa· 4 shared K. Mackie· 4 shared M. Gu· 3 shared M. J. Ouyang· 3 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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7 shared papersBioengineering

F. Guo

Mutual co-authors in cluster

Author profile →

12 papers

Recent·Most cited

Extracellular vesicles-based point-of-care testing for the diagnosis and monitoring of Alzheimer's disease

X. Li, J. Chen, y. yang, H. Cai, Z. Ao, Y. Xing, k. Li, K. Yang, A. Wallace, J. Friend, L. P. Lee, N. Wang, F. Guo

This paper presents an OECT-based sensor for rapid, sensitive detection of extracellular vesicles in Alzheimer's disease, showing improved sensitivity and reduced detection time.

bioRxiv · Mar 31, 2024Bioengineering

Oral immunization with rVSV bivalent vaccine elicits protective immune responses, including ADCC, against both SARS-CoV-2 and Influenza A viruses

M. J. Ouyang, Z. Ao, T. Olukitibi, P. Lawrynuik, C. Shieh, S. Kung, K. Fowke, D. Kobasa, X. Yao

bioRxiv · Jul 14, 2023Microbiology

Brain Organoid Computing for Artificial Intelligence

H. Cai, Z. Ao, C. Tian, Z. Wu, H. Liu, J. Tchieu, M. Gu, K. Mackie, F. Guo

The paper develops Brainoware, a living AI hardware using 3D brain organoids to compute nonlinear equations and demonstrate learning capabilities.

bioRxiv · Feb 28, 2023 · PreprintBioengineering

Engineering human spinal microphysiological systems to model opioid-induced tolerance

H. Cai, Z. Ao, C. Tian, Z. Wu, C. Kaurich, Z. Chen, M. Gu, A. G. Hohmann, K. Mackie, F. Guo

This paper develops human spinal microphysiological systems to model opioid-induced tolerance and hyperalgesia, showing altered neural activity and receptor downregulation with prolonged opioid exposure.

bioRxiv · Oct 3, 2022Bioengineering

Understanding immune-driven brain aging by human brain organoid microphysiological analysis platform

S. Song, Z. Ao, H. Cai, X. Li, Y. Miao, Z. Wu, J. Krzesniak, M. Gu, L. P. Lee, F. Guo

This study develops a human brain organoid microphysiological platform to model immune-driven brain aging by perfusing aged monocytes and observing their effects on organoid tissues.

bioRxiv · Jan 19, 2022 · PreprintBioengineering

Development and Characterization of Recombinant Vesicular Stomatitis Virus (rVSV)-based Bivalent Vaccine Against COVID-19 Delta Variant and Influenza Virus

Z. Ao, M. Jing Ouyang, T. A. Olukitibi, B. Warner, R. Vendramelli, T. Truong, M. Zhang, S. Kung, K. R. Fowke, D. Kobasa, X. Yao

This study develops and tests a bivalent rVSV vaccine targeting SARS-CoV-2 Delta and influenza, showing strong immune responses and protection in animal models.

bioRxiv · Dec 14, 2021 · PreprintMicrobiology

SARS-CoV-2 Delta Spike Protein Enhances the Viral Fusogenicity and Inflammatory Cytokine Production

Z. Ao, M. J. Ouyang, T. A. Olukitibi, X. Yao

This study shows that the Delta variant's spike protein enhances viral entry, cell fusion, and inflammatory cytokine production in immune cells.

bioRxiv · Nov 23, 2021Microbiology

Development and characterization of influenza M2 ectodomain and/or HA stalk-based DC-targeting vaccines for different influenza infections

X. Yao, T. Olukitibi, Z. Ao, H. Azizi, M. Mahmoudi, K. Coombs, D. Kobasa, G. Kobinger

This study develops and tests DC-targeting influenza vaccines based on EboGP domains, showing they induce strong antibody responses and protect mice against H1N1 and H3N2 influenza.

bioRxiv · Oct 7, 2021 · PreprintMicrobiology

Prunella vulgaris extract and suramin block SARS-coronavirus 2 virus Spike protein D614 and G614 variants mediated receptor association and virus entry in cell culture system

Z. Ao, M. Chan, M. J. Ouyang, T. A. Olukitibi, M. Mahmoudi, D. Kobasa, X. Yao

This study shows that Prunella vulgaris extract and suramin inhibit SARS-CoV-2 Spike protein-mediated virus entry and reduce cytopathic effects in cell cultures.

bioRxiv · Aug 28, 2020 · PreprintMicrobiology

Controllable Fusion of Human Brain Organoids Using Acoustofluidics

Z. Ao, H. Cai, Z. Wu, J. Johnathon, H. Wang, K. Mackie, F. Guo

This paper develops an acoustofluidic method to controllably fuse human brain organoids, enhancing standardization and reproducibility of fused models.

bioRxiv · Aug 5, 2020Bioengineering

Acoustofluidic Assembly of 3D Neurospheroids to Model Alzheimer's Disease

H. Cai, Z. Ao, L. Hu, Y. Moon, Z. Wu, H.-C. Lu, J. Kim, F. Guo

This paper introduces an acoustofluidic device to create 3D neurospheroids for modeling Alzheimer's disease neuroinflammation and amyloid-β toxicity.

bioRxiv · Mar 3, 2020Bioengineering

One-stop Microfluidic Assembly of Human Brain Organoids to Model Prenatal Cannabis Exposure

Z. Ao, H. Cai, D. Havert, Z. Wu, Z. Gong, J. Beggs, K. Mackie, F. Guo

This paper develops a microfluidic platform to assemble human brain organoids and models prenatal cannabis exposure effects on early brain development.

bioRxiv · Jan 15, 2020Bioengineering