Author

K. Makabe

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:experimental assay· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. Maejima· 1 shared A. Tsugita· 1 shared C. Gatsogiannis· 1 shared I. Kumagai· 1 shared I. Nakahara· 1 shared K. Sato· 1 shared M. Nazuka· 1 shared R. Asano· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

A. Maejima

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1 paper

Recent·Most cited

Structural basis for bispecific antibody design: arrangement of domain linkage produces activity enhancement

K. Sato, S. Uehara, A. Tsugita, S. Ishiyama, A. Maejima, I. Nakahara, M. Nazuka, T. Matsui, C. Gatsogiannis, T. Yokoyama, I. Kumagai, K. Makabe, R. Asano, Y. Tanaka

This study determines the cryo-EM structures of two bispecific antibody types and shows that domain linkage rearrangement leads to activity enhancement by altering complex shape and dynamics.

bioRxiv · Apr 25, 2024 · PreprintBiochemistry