Author

S. Uehara

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Plant Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:Arabidopsis· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. K. Hempton· 1 shared A. Maejima· 1 shared A. Nakahashi· 1 shared A. Sato· 1 shared A. Tsugita· 1 shared B. L. R. Downing· 1 shared C. Gatsogiannis· 1 shared C. Queitsch· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperPlant Biology

A. K. Hempton

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Florigen-producing cells express FPF1-LIKE PROTEIN 1 that accelerates flowering and stem growth in long days with sunlight red/far-red ratio in Arabidopsis

H. Takagi, N. Lee, A. K. Hempton, S. Purushwani, M. Notaguchi, K. Yamauchi, K. Shirai, Y. Kawakatsu, S. Uehara, W. G. Albers, B. L. R. Downing, S. Ito, T. Suzuki, T. Matsuura, I. C. Mori, , T. Imaizumi

The paper identifies FLP1 as a gene expressed in FT-producing cells in Arabidopsis that promotes flowering and stem growth under long-day conditions.

bioRxiv · Apr 26, 2024 · PreprintPlant Biology

Structural basis for bispecific antibody design: arrangement of domain linkage produces activity enhancement

K. Sato, S. Uehara, A. Tsugita, S. Ishiyama, A. Maejima, I. Nakahara, M. Nazuka, T. Matsui, C. Gatsogiannis, T. Yokoyama, I. Kumagai, K. Makabe, R. Asano, Y. Tanaka

This study determines the cryo-EM structures of two bispecific antibody types and shows that domain linkage rearrangement leads to activity enhancement by altering complex shape and dynamics.

bioRxiv · Apr 25, 2024 · PreprintBiochemistry

Discovery of S-217622, a Non-Covalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19

Y. Unoh, S. Uehara, K. Nakahara, H. Nobori, Y. Yamatsu, S. Yamamoto, Y. Maruyama, Y. Taoda, K. Kasamatsu, T. Suto, K. Kouki, A. Nakahashi, S. Kawashima, T. Sanaki, S. Toba, , Y. Tachibana

This paper describes the discovery of S-217622, an oral non-covalent SARS-CoV-2 3CL protease inhibitor showing antiviral activity and favorable pharmacokinetics in preclinical studies.

bioRxiv · Jan 26, 2022Biochemistry