Formation of multinucleated osteoclasts depends on an oxidized species of cell surface associated La protein
E. Leikina, J. M. Whitlock, K. Melikov, W. Zhang, M. P. Bachmann, L. Chernomordik
This study identifies an oxidized form of La protein at the osteoclast surface, driven by ROS signaling, which promotes multinucleation and bone resorption.
bioRxiv · May 2, 2024Cell Biology