K. Morishima

Conserved loop of a phase modifier endows protein condensates with fluidity

This study identifies Kapβ2 as a target of DPRs, showing how DPR binding alters its phase-modifying function, leading to toxic RBP condensates in ALS models.

Mechanistic modeling of amyloid oligomer and protofibril formation

This study establishes a mechanistic model of amyloid oligomer and protofibril formation in bovine insulin using light scattering and kinetic analysis, revealing end-to-end association as the rate-limiting step.

Orchestration of Proteins in cyanobacterial Circadian Clock System 1

This study reveals that the cyanobacterial circadian clock involves synchronized multiple association-dissociation reactions between Kai proteins, not a single process as previously thought.