M. Sugiyama

Comparison of monomeric variants of StayGold

This study compares three monomeric variants of StayGold to evaluate their photostability, brightness, and dispersibility, highlighting tradeoffs in fluorescent protein technology.

StayGold Photostability under Different Illumination Modes

This study compares the photostability of StayGold with three other FPs under different illumination modes in microscopy, finding that StayGold maintains superior photostability in multi-beam LSCM but shows variable performance in single-beam LSCM.

A new mathematical model of phyllotaxis to solve the genuine puzzle spiromonostichy

The paper develops a new mathematical model that incorporates both inhibitory and inductive effects to explain costoid phyllotaxis with spiromonostichy in Costus megalobractea.

Mechanistic modeling of amyloid oligomer and protofibril formation

This study establishes a mechanistic model of amyloid oligomer and protofibril formation in bovine insulin using light scattering and kinetic analysis, revealing end-to-end association as the rate-limiting step.

Subchronic Toxicity Assessment of Perfluoroalkyl Substances by Mixed Exposure of Nine Substances at Daily Intake Relevant Concentration

This study assesses the subchronic toxicity of a PFAS mixture in mice, finding liver morphological changes and alterations in metabolism and cancer-related gene expression.

The conserved upstream ORF of the Arabidopsis ANAC082 gene mediates translational upregulation in response to nucleolar stress

This study shows that the upstream ORF of the Arabidopsis ANAC082 gene enhances translation under nucleolar stress but not ER stress, indicating evolutionary loss of this regulatory mechanism in ANAC103.

Fatty Acid Synthase inhibitor TVB-3166 prevents S-acylation of the Spike protein of human coronaviruses.

This study shows that TVB-3166 inhibits S-acylation of coronavirus Spike proteins, reducing viral spread and improving survival in mice.

Orchestration of Proteins in cyanobacterial Circadian Clock System 1

This study reveals that the cyanobacterial circadian clock involves synchronized multiple association-dissociation reactions between Kai proteins, not a single process as previously thought.

LUZP1 regulates the constriction velocity of the contractile ring during cytokinesis

This study identifies LUZP1 as a novel regulator of cytokinesis by modulating the constriction velocity of the contractile ring through interactions with DAPK3 and MYL9.

Improved imaging and preservation of lysosome dynamics using silver nanoparticle-enhanced fluorescence

This paper demonstrates that silver nanoparticles enhance lysosome fluorescence, enabling live-cell imaging with reduced phototoxicity and preserved dynamics.

The association of ubiquitin-associated protein 2-like and Ras-GTP-activating protein SH3 domain binding protein 1 mediated by small nucleolar RNA is essential for stress granule formation

The paper identifies UBAP2L as a novel stress granule component that forms a protein-RNA complex with G3BP1 and snoRNAs, essential for stress granule formation.

Structural development of amyloid precursors in insulin B chain and the inhibition effect by fibrinogen

This study investigates the structural development of insulin B chain prefibrillar intermediates and how fibrinogen inhibits their fibril formation using multiple biophysical techniques.

The kinesin KIF4 mediates HBV/HDV entry through regulation of surface NTCP localization and can be targeted by RXR agonists in vitro.

This paper identifies KIF4 as a critical regulator of NTCP surface localization for HBV/HDV entry and shows RXR agonists can suppress KIF4 to inhibit viral infection.

Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease

Gonadotropin-releasing hormone increases the release of extracellular vesicles from gonadotropes

This study shows GnRH stimulates EV release from gonadotropes via ANXA5, with implications for hormonal regulation of cell communication.

MafF is an antiviral host factor that suppresses transcription from Hepatitis B Virus core promoter

This study identifies MafF as an antiviral host factor that suppresses HBV core promoter transcription, contributing to host defense against HBV infection.

Temperature-dependent fasciation mutants connect mitochondrial RNA processing to the control of cell proliferation during lateral root morphogenesis

Structural Studies of Overlapping Dinucleosomes in Solution

The paper investigates the solution structure of overlapping dinucleosomes using SAXS, SANS, modeling, and simulations, showing histone tails stabilize their conformations.

Direct Evidence of Effect of Glycerol on Hydration and Helix-to-Sheet Transition of Myoglobin

This paper investigates glycerol's effect on myoglobin's hydration and structural transitions using scattering techniques, showing preservation of hydration shells at low concentrations and structural stabilization at higher concentrations.