M. Matsusaki

Client recognition differences between PDI and ERp46 to guide oxidative folding

The paper compares how PDI and ERp46 recognize client proteins during oxidative folding, showing distinct mechanisms that influence disulfide bond formation and protein quality control.

Ultra-Rapid and Specific Gelation of Collagen Molecules for Transparent and Tough Gels by Transition Metal Complexation

This paper develops a method to rapidly form transparent and tough collagen gels using transition metal complexation, enabling deep-live cell observation in a mechanically tunable environment.

Fabrication of Molecular Blocks with High Responsiveness to the Cancer Microenvironment by Ursodeoxycholic Acid

This study identifies ursodeoxycholic acid (UDCA)-functionalized poly(vinyl alcohol) (PVA-UDCA) as a molecular block with high responsiveness to the cancer microenvironment and low cytotoxicity at neutral pH.

Fabrication of a Polymeric Inhibitor of Proximal Metabolic Enzymes in Hypoxia for Synergistic Inhibition of Cancer Cell Proliferation, Survival and Migration

This paper develops a polymeric inhibitor that targets multiple enzymes under hypoxia, showing synergistic effects in inhibiting cancer cell proliferation, survival, and migration.

Oxidative phase transition of heat shock factor-1

This study shows Hsf1 undergoes oxidative phase transition, forming gel-like droplets that drive cell fate decision via nuclear stress bodies.

Injectable prevascularized mature adipose tissues (iPAT) to achieve long-term survival in soft tissues regeneration

The paper develops injectable prevascularized adipose tissues (iPAT) that show improved cell survival and volume maintenance in mice after 3 months.

A unique adhesive motif of protein disulfide isomerase P5 supports its function via dimerization

This study identifies a unique adhesive motif in P5 that enables dimerization, which is essential for its structural stability and functional roles in ER quality control.