Author

K. N. Estep

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:mouse· 1

Frequent Co-Authors

F. B. Johnson· 3 shared J. W. Tobias· 2 shared R. J. Fernandez· 2 shared A. Babu· 1 shared B. M. Beveridge· 1 shared B. W. Katona· 1 shared C. J. Lengner· 1 shared C. Lengner· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCell Biology

F. B. Johnson

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Author profile →

3 papers

Recent·Most cited

Telomeric DNA breaks in human induced pluripotent stem cells trigger ATR-mediated arrest and telomerase-independent telomere length maintenance

K. N. Estep, J. W. Tobias, R. J. Fernandez, B. M. Beveridge, F. B. Johnson

This study investigates how human iPSCs respond to telomeric DNA breaks, showing ATR-mediated cell cycle arrest and telomerase-independent telomere maintenance via ALT.

bioRxiv · Jan 19, 2023 · PreprintCell Biology

APC and P53 mutations synergize to create a therapeutic vulnerability to NOTUM inhibition in advanced colorectal cancer

Y. Tian, X. Wang, Z. Cramer, J. Rhoades, K. N. Estep, X. Ma, S. A. Tzivelekidis, B. W. Katona, F. B. Johnson, Z. Yu, M. A. Blanco, C. Lengner, N. Li

This study identifies NOTUM as a therapeutic target in advanced colorectal cancer, showing that its inhibition effectively arrests tumor growth and metastasis in models with APC and P53 mutations.

bioRxiv · Jul 26, 2022 · PreprintCancer Biology

GSK3 inhibition rescues growth and telomere dysfunction in dyskeratosis congenita iPSC-derived type II alveolar epithelial cells

R. J. Fernandez, Z. J. G. Gardner, K. J. Slovik, D. C. Liberti, K. N. Estep, W. Yang, Q. Chen, G. T. Santini, J. V. Perez, S. Root, R. Bhatia, J. W. Tobias, A. Babu, M. P. Morley, D. B. Frank, , F. B. Johnson

This study shows that GSK3 inhibition improves growth and telomere function in DC patient-derived AT2 cells by enhancing Wnt signaling.

bioRxiv · Oct 28, 2020Cell Biology