Author

M. P. Morley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Research Focus:differential expression· 6 Approach:experimental assay· 5 Assay:bulk RNA-seq· 4 Organism:mouse· 4 Research Focus:cell-cell communication· 3 Approach:statistical model· 3 Organism:human· 2

Frequent Co-Authors

A. Babu· 5 shared E. E. Morrisey· 5 shared S. Zhou· 4 shared D. C. Liberti· 2 shared F. L. Cardenas-Diaz· 2 shared A. E. Vaughan· 1 shared A. Hinds· 1 shared A. M. Matschulat· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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5 shared papersCell Biology

A. Babu

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Author profile →

6 papers

Recent·Most cited

An injury-induced tissue niche shaped by mesenchymal plasticity coordinates the regenerative and disease response in the lung

D. L. Jones, M. P. Morley, X. Li, Y. Yun, F. L. Cardenas-Diaz, S. Li, S. Zhou, S. E. Schaefer, U. V. Chembazhi, A. Nottingham, S. Lin, E. Cantu, J. M. Diamond, M. C. Basil, A. E. Vaughan, E. E. Morrisey

The paper identifies an injury-induced tissue niche (iTCH) in the lung that coordinates regenerative and disease responses through mesenchymal plasticity and signaling pathways.

bioRxiv · Feb 26, 2024 · PreprintCell Biology

TGFβ controls alveolar type 1 epithelial cell plasticity and alveolar matrisome gene transcription

D. A. Callaway, I. J. Penkala, S. Zhou, F. Cardenas-Diaz, A. Babu, M. P. Morley, M. Lopes, B. Garcia, E. Morrisey

This study shows TGFβ signaling is essential for maintaining alveolar type 1 cell fate and regulates the alveolar matrisome through integrin transcription and mechanotransduction.

bioRxiv · May 9, 2023 · PreprintCell Biology

Generation of human alveolar epithelial type I cells from pluripotent stem cells

C. L. Burgess, J. Huang, P. Bawa, K.-D. Alysandratos, K. Minakin, M. P. Morley, A. Babu, C. Villacorta-Martin, A. Hinds, B. R. Thapa, F. Wang, A. M. Matschulat, E. E. Morrisey, X. Varelas, D. N. Kotton

This study generates human alveolar epithelial type I cells from iPSCs by activating YAP signaling, revealing Hippo-LATS-YAP's role in their differentiation.

bioRxiv · Jan 19, 2023Cell Biology

Atf3 defines a population of pulmonary endothelial cells essential for lung regeneration

T. K. Niethamer, L. I. Levin, M. P. Morley, A. Babu, S. Zhou, E. E. Morrisey

This study identifies Atf3 as critical for pulmonary endothelial regeneration after influenza infection, showing its role in endothelial proliferation, angiogenesis, and preventing alveolar damage.

bioRxiv · Oct 14, 2022Cell Biology

Temporal and spatial staging of lung alveolar regeneration is determined by the grainyhead transcription factor Tfcp2l1

F. L. Cardenas-Diaz, D. C. Liberti, J. P. Leach, A. Babu, J. Barasch, T. Shen, M. A. Diaz-Miranda, S. Zhou, Y. Ying, M. P. Morley, E. E. Morrisey

This study identifies Tfcp2l1 as a regulator of lung alveolar regeneration, balancing AT2 cell self-renewal and differentiation through spatial and temporal control.

bioRxiv · Aug 23, 2022Cell Biology

GSK3 inhibition rescues growth and telomere dysfunction in dyskeratosis congenita iPSC-derived type II alveolar epithelial cells

R. J. Fernandez, Z. J. G. Gardner, K. J. Slovik, D. C. Liberti, K. N. Estep, W. Yang, Q. Chen, G. T. Santini, J. V. Perez, S. Root, R. Bhatia, J. W. Tobias, A. Babu, M. P. Morley, D. B. Frank, , F. B. Johnson

This study shows that GSK3 inhibition improves growth and telomere function in DC patient-derived AT2 cells by enhancing Wnt signaling.

bioRxiv · Oct 28, 2020Cell Biology