Author

A. Babu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 8 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 8 Approach:experimental assay· 8 Research Focus:differential expression· 7 Assay:bulk RNA-seq· 5 Organism:mouse· 5 Approach:statistical model· 4 Research Focus:cell-cell communication· 3 Organism:human· 3

Frequent Co-Authors

E. E. Morrisey· 6 shared M. P. Morley· 6 shared S. Zhou· 4 shared D. B. Frank· 3 shared D. C. Liberti· 2 shared L. I. Levin· 2 shared M. C. Basil· 2 shared T. K. Niethamer· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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6 shared papersCell Biology

E. E. Morrisey

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Aberrant Transitional Alveolar Epithelial Cells Promote Pathogenic Activation of Lung Fibroblasts in Preclinical Fibrosis Modeling

E. T. Hoffman, W. R. Barboza, L. R. Rodriguez, R. Dherwani, Y. Tomer, A. Murthy, A. Bennett, A. Nottingham, A. Babu, K. Chavez, C. H. Cooper, M. C. Basil, M. S. B. Raredon, J. B. Katzen

This study identifies aberrant transitional alveolar epithelial cells in a mouse fibrosis model and shows they activate fibroblasts through a profibrotic secretome.

bioRxiv · Jun 17, 2024 · PreprintCell Biology

A longitudinal atlas of post-viral lung regeneration reveals persistent injury-associated cell states

T. K. Niethamer, J. D. Planer, M. P. Morley, A. Babu, M. C. Basil, E. Cantu, D. B. Frank, J. M. Diamond, A. N. Nottingham, S. Li, L. I. Levin, S. Zhou, E. E. Morrisey

This study maps the temporal sequence of mouse lung regeneration after viral injury, identifying persistent injury-associated cell states and their role in alveolar niche repair.

bioRxiv · May 24, 2024 · PreprintCell Biology

TGFβ controls alveolar type 1 epithelial cell plasticity and alveolar matrisome gene transcription

D. A. Callaway, I. J. Penkala, S. Zhou, F. Cardenas-Diaz, A. Babu, M. P. Morley, M. Lopes, B. Garcia, E. Morrisey

This study shows TGFβ signaling is essential for maintaining alveolar type 1 cell fate and regulates the alveolar matrisome through integrin transcription and mechanotransduction.

bioRxiv · May 9, 2023 · PreprintCell Biology

Generation of human alveolar epithelial type I cells from pluripotent stem cells

C. L. Burgess, J. Huang, P. Bawa, K.-D. Alysandratos, K. Minakin, M. P. Morley, A. Babu, C. Villacorta-Martin, A. Hinds, B. R. Thapa, F. Wang, A. M. Matschulat, E. E. Morrisey, X. Varelas, D. N. Kotton

This study generates human alveolar epithelial type I cells from iPSCs by activating YAP signaling, revealing Hippo-LATS-YAP's role in their differentiation.

bioRxiv · Jan 19, 2023Cell Biology

Atf3 defines a population of pulmonary endothelial cells essential for lung regeneration

T. K. Niethamer, L. I. Levin, M. P. Morley, A. Babu, S. Zhou, E. E. Morrisey

This study identifies Atf3 as critical for pulmonary endothelial regeneration after influenza infection, showing its role in endothelial proliferation, angiogenesis, and preventing alveolar damage.

bioRxiv · Oct 14, 2022Cell Biology

Temporal and spatial staging of lung alveolar regeneration is determined by the grainyhead transcription factor Tfcp2l1

F. L. Cardenas-Diaz, D. C. Liberti, J. P. Leach, A. Babu, J. Barasch, T. Shen, M. A. Diaz-Miranda, S. Zhou, Y. Ying, M. P. Morley, E. E. Morrisey

This study identifies Tfcp2l1 as a regulator of lung alveolar regeneration, balancing AT2 cell self-renewal and differentiation through spatial and temporal control.

bioRxiv · Aug 23, 2022Cell Biology

Circadian regulation of lung repair and regeneration

A. Naik, K. Forrest, Y. Issah, U. Valekunja, A. B. Reddy, E. Hennessy, T. Brooks, A. Babu, M. Morley, G. R. Grant, G. A. FitzGerald, A. Sehgal, G. S. Worthen, D. B. Frank, E. E. Morrisey, S. Sengupta

This study shows that the circadian clock regulates lung repair and regeneration independently of inflammation, identifies the Wnt/β-catenin pathway as a mediator, and links poor circadian rhythms to worse lung infection outcomes.

bioRxiv · Nov 20, 2021Cell Biology

GSK3 inhibition rescues growth and telomere dysfunction in dyskeratosis congenita iPSC-derived type II alveolar epithelial cells

R. J. Fernandez, Z. J. G. Gardner, K. J. Slovik, D. C. Liberti, K. N. Estep, W. Yang, Q. Chen, G. T. Santini, J. V. Perez, S. Root, R. Bhatia, J. W. Tobias, A. Babu, M. P. Morley, D. B. Frank, , F. B. Johnson

This study shows that GSK3 inhibition improves growth and telomere function in DC patient-derived AT2 cells by enhancing Wnt signaling.

bioRxiv · Oct 28, 2020Cell Biology

Antioxidant, Anti-inflammatory and Anticancer activities of Methanolic Extract of Thottea siliquosa: An In Vitro study

A. Koottasseri, A. Babu, A. Augustine, J. T. Job, A. Narayanankutty

bioRxiv · Mar 29, 2020Pharmacology & Toxicology