Author

K. O. West

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:gene regulatory network inference· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:genetic perturbation / CRISPR· 2 Assay:proteomics· 2

Frequent Co-Authors

K. L. PatrickiD· 3 shared R. O. WatsoniD· 3 shared A. P. West· 2 shared H. M. Scott· 2 shared S. Torres-Odio· 2 shared A. R. Wagner· 1 shared C. T. Hoffpauir· 1 shared G. Laliotis· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersImmunology

K. L. PatrickORCID

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4 papers

Recent·Most cited

PRMT5 promotes symmetric dimethylation of RNA processing proteins and modulates activated T cell alternative splicing and Ca2+/NFAT signaling

S. Sengupta, K. O. West, S. Sanghvi, G. Laliotis, L. M. Agosto, K. W. Lynch, P. Tsichlis, H. Singh, K. L. Patrick, M. Guerau-de-Arellano

This study identifies PRMT5's role in modulating alternative splicing and Ca2+/NFAT signaling in activated T cells through symmetric dimethylation of RNA processing proteins.

ImmunoHorizons · Oct 29, 2021Peer-reviewedImmunology

Global transcriptomics reveals specialized roles for splicing regulatory proteins in the macrophage innate immune response

K. O. West, A. R. Wagner, H. M. Scott, K. J. Vail, K. E. Carter, R. O. Watson, K. L. Patrick

This study identifies splicing regulatory proteins' roles in modulating macrophage gene expression during infection, showing their impact on immune gene induction and viral restriction.

bioRxiv · Dec 6, 2020Immunology

TRIM14 is a key regulator of the type I interferon response during Mycobacterium tuberculosis infection

C. T. Hoffpauir, S. L. Bell, K. O. West, T. Jing, S. Torres-Odio, J. S. Cox, A. P. West, P. Li, K. L. Patrick, R. O. Watson

This study identifies TRIM14 as a negative regulator of the type I interferon response in macrophages during Mycobacterium tuberculosis infection, showing it enhances resolution of the response and limits bacterial replication.

The Journal of Immunology · Jul 1, 2020Peer-reviewedImmunology

The splicing factor hnRNP M is a critical regulator of innate immune gene expression in macrophages

K. O. West, H. M. Scott, S. Torres-Odio, A. P. West, K. Patrick, R. O. Watson

This study shows that hnRNP M represses innate immune gene expression in macrophages and its phosphorylation by pathogen sensing cascades regulates splicing to control immune responses.

bioRxiv · Apr 30, 2019Immunology