Author

J. S. Cox

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Organism:mouse· 6 Assay:proteomics· 6 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Approach:genetic perturbation / CRISPR· 3

Frequent Co-Authors

H. M. Morrison· 3 shared J. M. Budzik· 3 shared J. R. Johnson· 3 shared N. J. Krogan· 3 shared T. Repasy· 3 shared A. Y. Lee· 2 shared C. E. Dodd· 2 shared D. A. Portnoy· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersImmunology

H. M. Morrison

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Mycobacterial formation of intracellular lipid inclusions is a dynamic process associated with rapid replication

D. M. Fines, D. Schichnes, M. Knight, A. Anaya-Sanchez, N. T. T. Thuong, J. S. Cox, S. Stanley

This study shows that mycobacteria form intracellular lipid inclusions during active replication without environmental stressors, challenging the link between ILI and non-replicating persistence.

bioRxiv · Aug 10, 2023 · PreprintMicrobiology

Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens

H. M. Morrison, J. Craft, R. Rivera-Lugo, J. R. Johnson, G. R. Golovkine, C. E. Dodd, E. Van Dis, W. L. Beatty, S. R. Margolis, T. Repasy, I. Shaker, A. Y. Lee, R. E. Vance, S. A. Stanley, N. J. Krogan, , J. S. Cox

bioRxiv · Dec 29, 2022 · PreprintImmunology

Cas9+ conditionally immortalized neutrophil progenitors as a tool for genome wide CRISPR screening for neutrophil differentiation and function

R. M. Jong, K. Ching, N. E. Garelis, A. Zilinskas, X. Nguyenla, S. Rawal, B. Hill, B. Luckie, L. Shallow, J. S. Cox, G. Barton, S. Stanley

This paper introduces a Cas9+ER-Hoxb8 neutrophil progenitor cell line for CRISPR screening to study neutrophil differentiation and function, identifying key genes like Cebpe and the WASH complex.

bioRxiv · Jul 19, 2022Immunology

IFN-γ-independent control of M. tuberculosis requires CD4 T cell-derived GM-CSF and activation of HIF-1α

E. Van Dis, H. M. Morrison, D. M. Fines, J. P. Babirye, L. H. McCann, S. Rawal, J. S. Cox, S. A. Stanley

This study identifies GM-CSF and HIF-1 activation as IFN-γ-independent mechanisms by which CD4 T cells control M. tuberculosis infection.

bioRxiv · Dec 16, 2021Immunology

Galectin-8 senses phagosomal damage and recruits selective autophagy adapter TAX1BP1 to control Mycobacterium tuberculosis infection in macrophages

S. L. Bell, K. L. Lopez, J. S. Cox, K. L. Patrick, R. O. Watson

This study identifies galectin-8 as a sensor for damaged Mtb-containing phagosomes that recruits TAX1BP1 to promote selective autophagy and control Mtb replication in macrophages.

mBio · Aug 31, 2021Peer-reviewedMicrobiology

Ceragenins and antimicrobial peptides kill bacteria through distinct mechanisms

G. Mitchell, M. R. Silvis, K. C. Talkington, J. M. Budzik, C. E. Dodd, J. M. Paluba, E. A. Oki, K. L. Trotta, D. J. Licht, D. Jimenez-Morales, S. Chou, P. B. Savage, C. A. Gross, M. A. Marletta, J. S. Cox

This study compares the mechanisms of action of cationic antimicrobial peptides and ceragenins, finding distinct bacterial responses despite some overlapping effects.

bioRxiv · Oct 20, 2020Microbiology

TRIM14 is a key regulator of the type I interferon response during Mycobacterium tuberculosis infection

C. T. Hoffpauir, S. L. Bell, K. O. West, T. Jing, S. Torres-Odio, J. S. Cox, A. P. West, P. Li, K. L. Patrick, R. O. Watson

This study identifies TRIM14 as a negative regulator of the type I interferon response in macrophages during Mycobacterium tuberculosis infection, showing it enhances resolution of the response and limits bacterial replication.

The Journal of Immunology · Jul 1, 2020Peer-reviewedImmunology

Comparative analysis of macrophage post-translational modifications during intracellular bacterial pathogen infection

J. R. Johnson, T. Parry, T. Repasy, K. M. Geiger, E. Verschueren, J. M. Budzik, D. Jimenez-Morales, B. W. Newton, E. Powell, L. Coscoy, D. A. Portnoy, N. J. Krogan, J. S. Cox

This study uses proteomics to analyze post-translational modifications in macrophages infected with three intracellular pathogens, revealing pathogen-specific molecular responses and a novel mechanism of virus-bacterial synergy.

bioRxiv · May 27, 2020 · PreprintMicrobiology

STING controls Herpes Simplex Virus in vivo independent of type I interferon induction

L. H. Yamashiro, S. C. Wilson, H. M. Morrison, V. Karalis, J.-Y. J. Chung, K. J. Chen, H. Bateup, M. L. Szpara, A. Y. Lee, J. S. Cox, R. Vance

This study shows that STING controls HSV-1 infection independently of type I interferon induction, through autophagy and other ancestral functions.

bioRxiv · Dec 12, 2019 · PreprintImmunology

Global proteomic profiling of primary macrophages during M. tuberculosis infection identifies TAX1BP1 as a mediator of autophagy targeting

J. M. Budzik, N. E. Garelis, T. Repasy, A. W. Roberts, L. Popov, T. J. Parry, D. Jiminez-Morales, D. Swaney, J. R. Johnson, N. J. Krogan, J. S. Cox

The paper uses proteomic analysis to identify TAX1BP1 as a mediator of autophagy targeting M. tuberculosis during macrophage infection.

bioRxiv · Jan 31, 2019 · PreprintMicrobiology