Author

K. J. Vail

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:differential expression· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

K. L. PatrickiD· 4 shared R. O. WatsoniD· 4 shared S. L. Bell· 3 shared C. G. Weindel· 2 shared A. I. Bordin· 1 shared A. K. Coleman· 1 shared A. R. Wagner· 1 shared B. Petri da Silveira· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersImmunology

K. L. PatrickORCID

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4 papers

Recent·Most cited

Mitochondrial dysfunction promotes alternative gasdermin D-mediated inflammatory cell death and susceptibility to infection

C. G. Weindel, X. Zhao, E. Martinez, S. L. Bell, K. J. Vail, A. K. Coleman, J. J. VanPortfliet, B. Zhao, C. Mabry, P. Li, P. West, J. Karpac, K. L. Patrick, R. O. Watson

This study shows that mitochondrial dysfunction caused by Lrrk2G2019S promotes non-pyroptotic cell death via GSDMD and increases susceptibility to infection.

bioRxiv · Nov 18, 2021 · PreprintImmunology

The opportunistic intracellular bacterial pathogen Rhodococcus equi elicits type I interferons by engaging cytosolic DNA sensing in macrophages

K. J. Vail, B. Petri da Silveira, S. L. Bell, A. I. Bordin, N. D. Cohen, K. L. Patrick, R. O. Watson

This paper shows that Rhodococcus equi triggers type I interferons in macrophages via cytosolic DNA sensing, independent of its virulence plasmid.

bioRxiv · Mar 28, 2021Immunology

Global transcriptomics reveals specialized roles for splicing regulatory proteins in the macrophage innate immune response

K. O. West, A. R. Wagner, H. M. Scott, K. J. Vail, K. E. Carter, R. O. Watson, K. L. Patrick

This study identifies splicing regulatory proteins' roles in modulating macrophage gene expression during infection, showing their impact on immune gene induction and viral restriction.

bioRxiv · Dec 6, 2020Immunology

LRRK2 regulates innate immune responses and neuroinflammation during Mycobacterium tuberculosis infection

C. G. Weindel, S. L. Bell, T. E. Huntington, K. J. Vail, R. Srinivasan, K. L. Patrick, R. O. Watson

This study shows LRRK2 regulates immune responses and neuroinflammation during Mycobacterium tuberculosis infection, linking it to neurodegenerative disease mechanisms.

bioRxiv · Jul 26, 2019Immunology