Author

K. W. Lynch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3 Immunology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 5 Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Y. Barash· 3 shared A. Thomas-Tikhonenko· 2 shared M. Quesnel-Vallieres· 2 shared A. A. Moverley· 1 shared A. Bagashev· 1 shared A. Jha· 1 shared A. S. Naqvi· 1 shared C. Li· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

Y. Barash

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies

X. Liu, S. A. Devadiga, R. F. Stanley, R. Moroow, K. Janssen, M. Quesnel-Vallieres, O. Pomp, A. A. Moverley, C. Li, N. Skuli, M. P. Carroll, J. Huang, D. C. Wallace, K. W. Lynch, O. Abdel-Wahab, P. S. Klein

This study shows that SRSF2 mutations disrupt mitochondrial mRNA splicing, impair complex I function, and increase mitophagy through a PINK1 splicing mechanism, identifying mitophagy as a therapeutic target in MDS and AML.

bioRxiv · Jun 25, 2023 · PreprintCancer Biology

RNase L-mediated RNA decay alters 3' end formation and splicing of host mRNAs

J. M. Burke, N. Ripin, M. B. Ferretti, L. A. St Clair, E. R. Worden-Sapper, S. L. Sawyer, R. Perera, K. W. Lynch, R. Parker

This study shows that RNase L-mediated RNA decay causes RNA-binding proteins to shift from cytoplasm to nucleus, altering splicing and 3' end formation of host mRNAs, especially interferons.

bioRxiv · Jan 28, 2022 · PreprintImmunology

Identifying common transcriptome signatures of cancer by interpreting deep learning models

A. Jha, M. Quesnel-Vallieres, A. Thomas-Tikhonenko, K. W. Lynch, Y. Barash

This study identifies common transcriptome signatures across cancer types using deep learning models trained on RNA-Seq data, revealing genes and splicing variations associated with cancer.

bioRxiv · Nov 11, 2021Cancer Biology

PRMT5 promotes symmetric dimethylation of RNA processing proteins and modulates activated T cell alternative splicing and Ca2+/NFAT signaling

S. Sengupta, K. O. West, S. Sanghvi, G. Laliotis, L. M. Agosto, K. W. Lynch, P. Tsichlis, H. Singh, K. L. Patrick, M. Guerau-de-Arellano

This study identifies PRMT5's role in modulating alternative splicing and Ca2+/NFAT signaling in activated T cells through symmetric dimethylation of RNA processing proteins.

ImmunoHorizons · Oct 29, 2021Peer-reviewedImmunology

Meta-Analysis of Transcriptomic Variation in T cell Populations Reveals Novel Signatures of Gene Expression and Splicing

C. M. Radens, D. Blake, P. Jewell, Y. Barash, K. W. Lynch

This study performs a meta-analysis of RNA-Seq data from human T cell subsets to identify consistent gene expression and splicing signatures across subtypes.

bioRxiv · Aug 9, 2019Immunology

Aberrant splicing in B-cell acute lymphoblastic leukemia

K. L. Black, A. S. Naqvi, K. E. Hayer, S. Y. Yang, E. Gillespie, A. Bagashev, V. Pillai, S. Tasian, M. R. Gazzara, M. Carroll, D. Taylor, K. W. Lynch, Y. Barash, A. Thomas-Tikhonenko

The paper identifies widespread aberrant splicing in pediatric B-ALL, showing that splicing factor deregulation drives splicing changes and contributes to disease.

Nucleic Acids Research · Oct 24, 2018Peer-reviewedCancer Biology