Author

K. Pelka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Assay:scRNA-seq· 3 Assay:spatial transcriptomics· 3 Approach:statistical model· 3 Research Focus:cell-cell communication· 2 Approach:deep learning· 2 Research Focus:spatial domain detection· 2

Frequent Co-Authors

J. Chen· 3 shared M. Hofree· 3 shared N. Hacohen· 3 shared V. Jorgji· 3 shared A. Mehta· 2 shared D. Dionne· 2 shared G. M. Boland· 2 shared J. D. Pirl· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

J. Chen

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Spatial analysis of human lung cancer reveals organized immune hubs enriched for stem-like CD8 T cells and associated with immunotherapy response

J. H. Chen, L. T. Nieman, M. Spurrell, V. Jorgji, P. M. Richieri, K. H. Xu, R. Madhu, M. Parikh, I. Zamora, A. Mehta, C. S. Nabel, S. S. Freeman, J. D. Pirl, C. Lu, C. B. Meador, , N. Hacohen

The paper identifies immune hubs in lung cancer that are associated with better responses to PD-1-blockade immunotherapy and contain stem-like CD8 T cells.

bioRxiv · Apr 4, 2023Immunology

Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics

I. Avraham-Davidi, S. Mages, J. Klughammer, N. Moriel, S. Imada, M. Hofree, E. Murray, J. Chen, K. Pelka, A. Mehta, G. M. Boland, T. M. Delorey, L. Caplan, D. Dionne, R. Strasser, , A. Regev

The paper combines single cell and spatial transcriptomics to map spatial organization and functional interactions in colorectal cancer across species.

bioRxiv · Oct 2, 2022Cancer Biology

Altered interactions between circulating and tissue-resident CD8 T cells with the colonic mucosa define colitis associated with immune checkpoint inhibitors

M. Thomas, K. Slowikowski, K. Manakongtreecheep, P. Sen, J. Tantivit, M. Nasrallah, N. Smith, S. Ramesh, L. Zubiri, A. Tirard, B. Arnold, L. Nieman, J. Chen, T. Eisenhaure, K. Pelka, , A.-C. Villani

This study identifies altered interactions between circulating and tissue-resident CD8 T cells with the colonic mucosa in immune checkpoint inhibitor-associated colitis using single-cell RNA sequencing and other multi-omics approaches.

bioRxiv · Sep 17, 2021Immunology

Multicellular immune hubs and their organization in MMRd and MMRp colorectal cancer

K. Pelka, M. Hofree, J. Chen, S. Sarkizova, J. D. Pirl, V. Jorgji, A. Bejnood, D. Dionne, W. H. Ge, K. H. Xu, S. X. Chao, D. R. Zollinger, D. J. Lieb, J. W. Reeves, C. A. Fuhrman, , J

The paper identifies immune hubs in colorectal cancer by analyzing transcriptional and spatial patterns in MMRd and MMRp tumors.

bioRxiv · Jan 30, 2021 · PreprintCancer Biology