Author

D. J. Lieb

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Organism:human· 6 Research Focus:differential expression· 5 Assay:scRNA-seq· 5 Research Focus:cell-cell communication· 3 Approach:experimental assay· 3 Assay:flow cytometry· 3 Approach:statistical model· 3

Frequent Co-Authors

N. Hacohen· 5 shared C. Nusbaum· 3 shared D. A. Rao· 3 shared J. A. Lederer· 3 shared S. Li· 3 shared S. Raychaudhuri· 3 shared T. M. Eisenhaure· 3 shared A. Arazi· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersImmunology

N. Hacohen

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Intrarenal myeloid subsets associated with kidney injury are comparable in mice and patients with lupus nephritis

P. Hoover, D. J. Lieb, J. Kang, S. Li, M. Peters, C. Raparia, A. Arazi, T. Eisenhaure, S. S. Gurajala, Q. Xiao, R. Mishra, M. Spurrell, R. Menon, M. Kretzler, J. Chen, , A. Davidson

This study identifies conserved myeloid subsets and disease-associated gene expression changes in kidney injury across lupus mouse models and human patients with lupus nephritis.

bioRxiv · Jun 24, 2023 · PreprintImmunology

Cytotoxic CD4+ T cells eliminate senescent cells by targeting cytomegalovirus antigen

T. Hasegawa, T. Oka, H. G. Son, V. S. Oliver-Garcia, M. Azin, T. M. Eisenhaure, D. J. Lieb, N. Hacohen, S. Demehri

The paper shows that cytotoxic CD4+ T cells eliminate senescent fibroblasts by targeting HCMV-gB antigen expressed on these cells, reducing their accumulation in old skin.

bioRxiv · Mar 6, 2023Immunology

Multicellular immune hubs and their organization in MMRd and MMRp colorectal cancer

K. Pelka, M. Hofree, J. Chen, S. Sarkizova, J. D. Pirl, V. Jorgji, A. Bejnood, D. Dionne, W. H. Ge, K. H. Xu, S. X. Chao, D. R. Zollinger, D. J. Lieb, J. W. Reeves, C. A. Fuhrman, , J

The paper identifies immune hubs in colorectal cancer by analyzing transcriptional and spatial patterns in MMRd and MMRp tumors.

bioRxiv · Jan 30, 2021 · PreprintCancer Biology

The immune cell landscape in kidneys of lupus nephritis patients

A. Arazi, D. A. Rao, C. C. Berthier, A. Davidson, Y. Liu, P. J. Hoover, A. Chicoine, T. M. Eisenhaure, A. H. Jonsson, S. Li, D. J. Lieb, E. P. Browne, A. Noma, D. Sutherby, S. Steelman, , B. Diamond

This study uses single-cell RNA-seq to analyze immune cell subsets in lupus nephritis kidneys, identifying pro-inflammatory and resolving responses and potential therapeutic targets.

bioRxiv · Jul 7, 2018Immunology

Defining Inflammatory Cell States in Rheumatoid Arthritis Joint Synovial Tissues by Integrating Single-cell Transcriptomics and Mass Cytometry

F. Zhang, K. Wei, K. Slowikowski, C. Y. Fonseka, D. A. Rao, S. Kelly, S. M. Goodman, D. Tabechian, L. B. Hughes, K. Salomon-Escoto, G. F. M. Watts, W. Apruzzese, D. J. Lieb, D. L. Boyle, A. M. Mandelin, , S. Raychaudhuri

The paper identifies key inflammatory cell states in RA synovial tissues using integrated single-cell and mass cytometry data from patient samples.

bioRxiv · Jun 20, 2018Immunology

High dimensional analyses of cells dissociated from cryopreserved synovial tissue

L. T. Donlin, D. A. Rao, K. Wei, K. Slowikowski, M. J. McGeachy, J. D. Turner, N. Meednu, F. Mizoguchi, M. Gutierrez-Arcelus, D. J. Lieb, J. Keegan, K. Muskat, J. Hillman, C. Rozo, E. Ricker, , M. B Brenner

This paper establishes a protocol for dissociating cryopreserved synovial tissue to obtain viable cells with preserved transcriptomes and surface markers, enabling high-dimensional analysis of rheumatoid arthritis pathology.

bioRxiv · Mar 19, 2018Immunology